UNIVERSITAS AIRLANGGA



Detail Article

Berkala Ilmiah Kimia Farmasi

ISSN 2302-8270

Vol. 4 / No. 2 / Published : 2015-11

Order : 4, and page :19 - 26

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Original Article :

Aktivitas invitro enzim fibrinolitik ekstrak tempe hasil fermentasi rhizopus oligosporus atcc 6010 pada substrat kedelai hitam

Author :

  1. ACHMAD TOTO POERNOMO*1
  2. ISNAENI*2
  3. PURWANTO*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

Screening of fibrinolytic activity of tempeh extract derived from Rhizopus oligosporus ATCC 6010 fermentation has been investigated. The fermentation used Glycine Soja Sieb. et Zucc, Canavalia ensiformis, Phaseolus radiaus L., Lablab purpureus,  Glysine  max (L) Merrill, Glycine Soja Sieb. et Zucc, and Vigna  unguiculata as substrates. Nattokinase and phosphate buffer 0,05 M pH 5,0 was used as positive and negative control respectively. The proteolytic and fibrinolytic activity of fermentation product used five kinds of legumes has been compared each other. The Glycine Soja Sieb. et Zucc exhibited the highest activity with proteolytic and fibrinolytic index of the crude enzyme is 3.00 ± 1.58 and 3,07 ± 0,15 respectively. Ratio of the proteolytic and fibrinolytic index between the crude enzyme and nattokinase is 112,36 % and 88,14% respectively.      

Keyword :

Fibrinolytic, trombosis, tempeh extract, hizopus oligosporus ATCC 6010.,


References :

Ashipala, O. K., He, Q,(2007) Optimization of fibrinolytic enzyme production by Bacillus subtilis DC 02 in aqueous two-phase system (poly-ethylene glycol 4000 and sodium sulfate). 99, pp. 4112-4119 : Biosource Technology





Archive Article

Cover Media Content

Volume : 4 / No. : 2 / Pub. : 2015-11
  1. Perbandingan Metode Spektrofotometri Sinar Tampak Dan Titrasi Kompleksometri Untuk Penentuan Kadar Zink Dalam Sediaan Sirup
  2. Pengaruh Substituen 2-metoksi Pada Sintesis Turunan 2-hidroksibenzohidrazida Dengan Iradiasi Gelombang Mikro
  3. Isolasi Dan Penapisan Fibrinolitik Jamur Tanah Hutan Mangrove Wonorejo Surabaya
  4. Aktivitas Invitro Enzim Fibrinolitik Ekstrak Tempe Hasil Fermentasi Rhizopus Oligosporus Atcc 6010 Pada Substrat Kedelai Hitam
  5. Perbandingan Metode Penentuan Kadar Oksitetrasiklin Dalam Udang Dengan Klt-densitometri Dan Klt-bioautografi
  6. Analisis Kandungan Lemak Dan Protein Terhadap Kualitas Soyghurt Dengan Penambahan Susu Skim
  7. Validasi Metode Kromatografi Lapis Tipis–densitometriuntuk Analisis Pewarna Merah Sintentikpada Beberapa Merek Saus Sambal Sachet

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