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Berkala Ilmiah Kimia Farmasi

ISSN 2302-8270

Vol. 2 / No. 2 / Published : 2013-11

TOC : 1, and page :1 - 4

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Original Article :

Uji aktivitas analgesik senyawa baru turunan parasetamol pada mencit (mus musculus) dengan metode hot plate

Author :

  1. Tri Widiandani*1
  2. Siswandono*2
  3. Suko Hardjono*3
  4. Istifada*4
  5. Risma Zahra*5
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Mahasiswa Fakultas Farmasi
  5. Mahasiswa Fakultas Farmasi

Abstract :

Paracetamol is analgesic drug that is widely used in Indonesia. A modification of paracetamol structure had been conducted which produced two compounds of paracetamol derivatives, that are 4’-acetamidophenyl-2-chlorobenzoat and 4’-acetamidophenyl-3-chlorobenzoat. These compounds are expected to carry bigger activity compared to paracetamol since they have higher lipofility. The purpose of  this research was to determine an analgesic activity of new parasetamol derivatives.   The analgesic activity test was administered using hot plate method in 550C ± 0,50C using mouse as an animal test. Analgesic activity was determined by noting down predrug latency and postdrug latency at the 30th, 60th, 90th, and 120th minutes after the assignment of control supply of CMC-Na 0,5%, paracetamol as a comparison (100 mg/kg BB) and compound test 1 and 2 (100 mg/kg BB) to each mouse group. The result of Maximum Possible Effect produced compound 1 MPE of 29,7% and compound 2 MPE of 37,04%. Based on the statistical analysis of ANOVA test, it can be concluded that the difference of activities is meaningful in the 60th minute after drug supply.  An analysis on stability, toxicity, physical, chemical and pharmacological nature of the new compounds derivative of paracetamol is also recommended.  

Keyword :

paracetamol,


References :

  1. Besse, D., Delchambre, C., Hanoun, N., Hamon, M., Eschalier, A., Caussade, F., Cloarec, A., (2001). Acetaminophen Distribution In The Rat Central Nervous System. . Journal : Life Sciences 69
  2. Burke, A., Smyte E., Fitz Gerald G. A.,, (2006). Analgesic-antipyretic agents; pharmacotherapy of gaout. In: Brunton, L.L (eds). Goodman and Gilman’s The Pharmacological Basic of Therapeutics. New York : McGraw-Hill


   


Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2013-11
  1. Uji aktivitas analgesik senyawa baru turunan parasetamol pada mencit (mus musculus) dengan metode hot plate
  2. Validasi metode kromatografi lapis tipis-densitometri untuk penetapan kadar kolkisin dalam infus daun kembang sungsang (gloriosa superba linn.)
  3. Penetapan kadar formalin dalam ayam potong yang diambil di pasar tradisional surabaya timur
  4. Pemodelan molekul dan hubungan kuantitatif struktur-aktivitas sitotoksik turunan benzoilurea sebagai antitumor
  5. Kandungan salisilat bebas dalam tablet asetosal yang beredar di surabaya
  6. Pemanfaatan daun trembesi (samanea saman) dalam mengadsorpsi logam berat timbal
  7. Perbandingan aktivitas penekan susunan saraf pusat senyawa baru n-benzoilfenilurea dan 4-nitrobenzoilfenilurea