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BIOSAINS

ISSN 1412-1433

Vol. 14 / No. 2 / Published : 2012-05

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Original Article :

Analysis of myoc gene polymorphism among malay race patients with primary open angle glaucoma in palembang

Author :

  1. Fidalia* ,*1
  2. Wisnujono Soewono**,*2
  3. Soetjipto**, *3
  4. FM. Judajana***4
  1. Fakultas Kedokteran Universitas Sriwijaya
  2. Fakultas Kedokteran Universitas Airlangga
  3. Fakultas Kedokteran Universitas Airlangga
  4. Fakultas Kedokteran Universitas Airlangga

Abstract :

Glaucoma is the second leading cause of blindness worldwide, recorded more than 67 million people, almost 2% of the global populationolder than 40 years. Primary Open Angle Glaucoma (POAG) is the most common type of glaucoma. In Indonesia, glaucoma is thesecond cause of blindness after cataract. Defects in the myocilin gene (MYOC) have been shown to be associated with POAG. There isno reported about analysis of MYOC gene polymorphism in relation to occurance of POAG in Malay race especially from Malay racein Palembang. The purpose of this study was to analyze polymorphism of MYOC gene among POAG Malay race patients in Palembang.Study design of this research is observational analytic comparative study type using cross sectional design. Analyze polymorphism ofMYOC gene was done by restriction fragment length polymorphism (RFLP) technique using restriction enzyme Ava1 and confi rmationsequencing, among 50 unrelated POAG compared with 50 non POAG Malay race in Dr. Moch. Hoesin Hospital Palembang. Therewere signifi cant difference genotype and alelle MYOC gene polymorphism in exon 1 and exon 3 between unrelated POAG patients andnon POAG patients (p < 0.001). This study suggested that there were relationship between MYOC gene polymorphism and occuranceof POAG Malay race patients in Palembang.

Keyword :

POAG; , MYOC Gene Polymorphism, , Malay race in Palembang,


References :

  1. Allingham RR, Wiggs JL, De La Paz MA, et al.,, (1998). Gln368Stop Myocilin mutation in families with late onset primary angle glaucoma. . - : Invest Ophthalmol.
  2. Alward WL, Fingert JH, Coote MA, et al., , (1998). Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLCIA).. England : J. Med
  3. Depkes RI., (1997). Survei Kesehatan Indra Penglihatan. 1993– 1996. . Jakarta : Depkes RI.
  4. Foster PJ, Oen FT, Machin D, et al.,, (2002). The defi nition and classifi cation of glaucoma in prevalence surveys. . - : Br J Opthalmol
  5. Gong G, Lasaki OK, Haynatzky GR, Wilson MR,, (2004). Genetic dissection of myocillin glaucoma. . - : Human Moleculer Genetic


   


Archive Article

Cover Media Content

Volume : 14 / No. : 2 / Pub. : 2012-05
  1. Analysis of myoc gene polymorphism among malay race patients with primary open angle glaucoma in palembang
  2. Polymorphism analysis of alpha–helix coiled coil rod homologue gene exon 2 to patients with psoriasis in palembang malay race
  3. Isolation and identification of high cellulolytic activity of bacteria from golden snail’s (pomacea canaliculata) gut
  4. Biocompability of low dose of human menopause gonadotropin(hmg) and deglycosilation of human menopause gonadotropine (dghmg) against bovine eggs
  5. Profile of narcotic evidence from black circulation market in law police area east java using gc-ms method
  6. Analysis the influence of time and detergen washing to dna from cement liquids spotted in fga locus, d21s11 and dys19 using str-pcr method
  7. The analyze of human dna soft tissue that contaminated formalin during 1 month and 6 month at locus d13s317 using str-pcr