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ISSN 1412-1433

Vol. 14 / No. 1 / Published : 2012-01

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Original Article :

Mechanism of hypersensitivity pneumonitis (hp) as a result from the exposure of dust from paddy milling on mice (mus musculus) balb/c

Author :

  1. Isa Ma’rufi *1
  2. Kuntoro*2
  3. Soedjajadi Keman*3
  4. JF. Palilingan*4
  1. Fakultas Kesehatan Masyarakat Universitas Jember
  2. Fakultas Kesehatan Masyarakat Universitas Airlangga
  3. Fakultas Kesehatan Masyarakat Universitas Airlangga
  4. Fakultas Kedokteran Universitas Airlangga

Abstract :

The purpose of this research was to analyze the immune response mechanism of Hypersensitivity Pneumonitis (HP) as a result fromthe exposure of dust from paddy milling on mice (Mus musculus)BALB/C. The research done was a laboratory experimental researchwith mice (Mus musculus) as experimental animal. The research design used was the post only control group design using mice (Musmusculus) Balb/c as experimental animal. Mice (Mus musculus) BALB/C were exposed to dust from paddy milling for four (4) hours/dayand it was done for thirty (30) days with the exposed concentrations respectively were 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3.The researchvariables were free variable, dependent variable, and control variable. Independent variable was dust from paddy milling, dependentvariables were Hypersensitivity Pneumonitis (HP), IgE, IL-4, CD8, IFN-γ, infl ammatory cells, and histopathological picture of micelung, while control variables were strain, body weight and age of mice (Mus musculus) BALB/C. The research result showed that therewas an increased of IgE, yet statistically there was no signifi cant difference; there was an increase on IL-4, CD-8, IFN-γ, infl ammatorycells and lung histopathology and statistically there was a signifi cant difference between the study and control on mice BALB/C. Theconclusion of the research was that the immune response mechanism of Hypersensitivity Pneumonitis (HP) as a result from the exposureof dust from paddy milling on mice (Mus musculus) BALB/C. It could be concluded that dust from paddy milling inhaled repeatedlypassed into the alveoli and then it was caught by alveolar macrophages which then generated the increase of IL-4 and CD-8. Afterthat, IL-4 generated the increase of IgE which afterward attracted mast cells while CD8 expressed IFN-γ which then activated alveolarmacrophages and attracted a number of neutrophil and mast cell which subsequently induced infl ammation. The infl ammation occurredwould develop into other tissue damage and led to Hypersensitivity Pneumonitis (HP). It was suggested that: it be better to repeat withlonger exposure time so that the damage in lung be seen more clearly especially the occurrence of granuloma in lung.

Keyword :

Hypersensitivity Pneumonitis (HP), dust from paddy milling,

References :

  1. Ancillo M, Domínguez-Noche C, Gil-Adrados AC, Cosmes PM,, (2004). Hypersensitivity pneumonitis due to occupational inhalation of fungicontaminated corn dust. . - : J Invest Allergol Clin Immunol
  2. Barrera L, Felipe M, Joaquı´n, Andrea E, Ana CZ, and Emma I,, (2008). Functional diversity of Tcell subpopulations in subacute and chronic hypersensitivity pneumonitis. . - : Am J Respir Crit Care Med,
  3. Cormier Y and Schuyler M, (2006). Hypersensitivity pneumonitis and organic dust toxic syndromes. In Bernstein L (ed). Asthma in the workplace, 3rd ed. . New York : Taylor & Francis Goup.


Archive Article

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Volume : 14 / No. : 1 / Pub. : 2012-01
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  2. Mechanism of hypersensitivity pneumonitis (hp) as a result from the exposure of dust from paddy milling on mice (mus musculus) balb/c
  3. Under fives nutritional rearing model based on risk factors approach
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