UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 19 / No. 3 / Published : 2013-01

Order : 12, and page :204 - 210

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Original Article :

(cell based hemostatis – in vivo)

Author :

  1. Liong Boy Kurniawan*1
  2. Mansyur Arif*2
  1. Bagian Ilmu Patologi Klinik FK-UNHAS/RSUP Dr. Wahidin Sudirohusodo Makassar
  2. Bagian Ilmu Patologi Klinik FK-UNHAS/RSUP Dr. Wahidin Sudirohusodo Makassar

Abstract :

Understanding of hemostasis has developed substantially in the last century from stasis in vitro to in vivo concept. Hemostasis theory develops from classic theory, discovery of coagulation factors leading to cascade/waterfall theory, as well as to in vivo cell based theory which explains the limitations of cascade theory. Phases of cell based hemostasis theory include initiation, amplification, propagation and termination with the role of tissue factor, platelet activation and coagulation factors in thrombin and fibrin synthesis. Common hemostasis tests used nowadays are important in evaluating bleeding risk but this matter still can not explain cell based hemostasis theory comprehensively so we need to find new tests to evaluate in vivo hemostasis.   Pemahaman penghentian perdarahan (hemostasis) telah berkembang secara substansial sejak 1 abad terakhir, mulai dari pemahaman secara stasis antara lingkungan buatan dan lingkungan hidup. Teori hemostasis mengalami perkembangan, mulai dari yang lama, penemuan faktor penggumpalan darah (koagulasi) yang mencetuskan teori kaskade/waterfall secara lingkungan buatan hingga yang berlandaskan sel. Yaitu yang menjelaskan kekurangan teori kaskade secara lingkungan hidup. Tahapan dalam hemostasis berlandaskan sel mencakup tahap awal, penguatan, pengembangbiakan (propagasi) dan diakhiri dengan pengakhiran. Tahapan tersebut melibatkan peran utama faktor jaringan, aktivasi trombosit dan faktor koagulasi dalam pembentukan trombin dan fibrin. Uji hemostasis yang umum digunakan saat ini penting dalam menilai kebahayaan perdarahan, tetapi masih belum dapat menjelaskan yang berlandaskan sel secara lebih mendalam, sehingga diperlukan penemuan uji baru dalam menilai hemostasis secara lingkungan hidup.

Keyword :

Cell based hemostasis, , in vivo,


References :

1. Riddel Jr JP, Aouizerat BE, Miaskowski C, Lillicrap DP,(2007) Theories of blood Coagulation USA : J of Ped Oncol Nurs

Ruseva AL, Dimitrova AA,(2011) A New Understanding of The Coagulation Process-The Cell Based Model. J Biomed Clin Res USA : J Biomed Clin Res

Smith SA,(2009) The Cell-Based Model of Coagulation USA : J Vet Emerg Crit Care

Giangrande P,(2003) Six Characters in Search of an Author: The History of The Nomenclatur of Coagulation Factors British : British J of Hematol

Roberts HR, Monroe DM, Escobar MA,(2004) Current Concepts of Hemostasis Implication for Therapy USA : Anasthesiology





Archive Article

Cover Media Content

Volume : 19 / No. : 3 / Pub. : 2013-01
  1. {(active Caspase-3 In Acute Myeloid Leukaemia (aml) And Acute Lymphoblastic Leukaemia (all)}
  2. (principle Modification Of β-glucan Detection From Candida Albicans In Serum)
  3. Apoptosis Index Between Females And Males In Regular Hemodialysis
  4. [iron Deficiency In Pregnant Women By Haemoglobin Reticulocyte (ret-he)]
  5. (higher Level Of Ctx In Osteoporotic Women Compared To Normal And Osteopenic Women)
  6. (cystatin C, Hba1c And Albumin Creatinine Ratio)
  7. (lactate Dehydrogenase (ldh) During Storage)
  8. (cd4+ T Lymphocyte As A Prognosis Predictor In Sepsis Patients)
  9. (angiotensin Ii On Adipocytes Culture Exposed With High Glucose)
  10. (the Panleucogating Method For Lymphocyte Cd4 Counting In Hiv Patients)
  11. (c3c Serum Complement And Blood T-cd4+ Lymphocyte)
  12. (cell Based Hemostatis – In Vivo)
  13. Neonatal Acute Myeloid Leukaemia

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