UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 19 / No. 3 / Published : 2001-01

Order : 6, and page :167 - 173

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Original Article :

(cystatin c, hba1c and albumin creatinine ratio)

Author :

  1. Juliani Dewi*1
  1. Laboratorium Klinik Prodia Cabang Malang

Abstract :

Prevalence of type 2 diabetes mellitus and chronic kidney disease is increasing nowdays. Cystatin C is a more sensitive marker in detecting  kidney disturbance at an early stage. Microalbuminuria indicates that there is an increasing risk in kidney disorders in diabetes mellitus patients. HbA1C is used to assess average blood glucose  in three (3) months. An evaluation about the relation among Cystatin C, HbA1C, and ACR is needed to decide which test will be appropriate for the patient. Cystatin C was determined using Particle-enhanced nephelometric immunoassay (PENIA) method from BN Prospec. High Performance Liquid Chromatography (HPLC) method from BioRad was used for HbA1C test, while random urine sample was used for Albumin Creatinine Ratio (ACR) test. Urine and serum creatinine were tested by immunoturbidimetric assay from Cobas C501. Correlation among Cystatin C, HbA1C, and ACR was estimated using Spearman’s correlation test. There was a significant correlation among Cystatin, HbA1C, and ACR. Spearman correlation value showed a positive weak correlation. There was a strong relation between Cystatin C and HbA1C, but weak relations between Cystatin C and ACR, and between HbA1C and ACR. It can be concluded that  due to  the weak correlation between ACR and kidney function as well as between ACR and HbA1C, ACR is not a good assessment to predict diabetic nephropathy progressiveness.     Jumlah penyakit diabetes melitus dan gangguan ginjal kronis semakin meningkat. Di penderita diabetes melitus jenis 2, Cystatin C merupakan petanda perubahan GFR yang lebih peka dalam menemukan gangguan ginjal dini. Mikroalbuminuria menandakan peningkatan kebahayaan gangguan ginjal di penderita diabetes melitus terjadi. Hemoglobin A1C (HbA1C) digunakan untuk menilai rerata kadar gula dalam tiga (3) bulan. Penilaian hubungan antara Cystatin C, HbA1C, dan ACR diperlukan untuk membantu pemilihan uji yang sesuai dengan keperluan penderita. Pemeriksaan Cystatin C dilakukan menggunakan metode PENIA dan alat  BN Prospec. Pemeriksaan HbA1C menggunakan metode HPLC buatan BioRad. Pemeriksaan rasio albumin kreatinin air kemih menggunakan sampel sewaktu. Kreatinin air kemih dan albuminnya diperiksa dengan metode imunoturbidimetri, menggunakan alat Cobas C501. Data dianalisis secara statistik menggunakan uji Spearman. Pada pemeriksaan ditemukan ada kenasaban yang  bermakna antara Cystatin C,  HbA1C, dan rasio albumin kreatinin air kemih. Nilai kenasaban Spearman menunjukkan bahwa arahnya positif dengan kekuatan yang lemah. Antara  kadar Cystatin C dan HbA1C-nya terdapat hubungan yang kuat, tetapi hubungan antara kadarnya seseorang dan rasio  albumin kreatinin air kemih lemah. Juga hubungan antara HbA1C perorangan masing-masing dengan rasio albumin kreatinin air kemih lemah. Didasari kajian ini, diketahui bahwa kenasaban antara ACR dan fungsi ginjal maupun HbA1C walaupun ada tetapi lemah, sehingga uji yang disebut pertama kurang dapat digunakan untuk meramalkan perkembangan penyakit ginjal akibat kencing manis (nefropati diabetik).

Keyword :

Cystatin C, HbA1C, ACR, diabetic nephropathy,


References :

Aslan D,(2011) Biomarkers for Diabetes Complications: The Results of Several Clinical Studies USA : J Med Biochem

Cho HC,(2010) The Association between Serum GGT Concentration and Diabetic Peripheral Polyneuropathy in Type 2 Diabetic Patients Korea : Korean Diabetes J

Mohammad YMM,(2010) Assessment of Early Renal Impairment in Type 1 Diabetic Children and Adolescents With and Without Microalbuminuria [Thesis] Shams : Faculty of Medicine Ain Shams University

Radbill B, Murphy B, LeRoith D,(2008) Rationale and Strategies for Early Detection and Management of Diabetic Kidney Disease USA : Mayo Clin Proc

Obineche EN, Adem A,(2005) Update in Diabetic Nephropathy USA : Int J Diabetes & Metabolism





Archive Article

Cover Media Content

Volume : 19 / No. : 3 / Pub. : 2013-01
  1. {(active Caspase-3 In Acute Myeloid Leukaemia (aml) And Acute Lymphoblastic Leukaemia (all)}
  2. (principle Modification Of β-glucan Detection From Candida Albicans In Serum)
  3. Apoptosis Index Between Females And Males In Regular Hemodialysis
  4. [iron Deficiency In Pregnant Women By Haemoglobin Reticulocyte (ret-he)]
  5. (higher Level Of Ctx In Osteoporotic Women Compared To Normal And Osteopenic Women)
  6. (cystatin C, Hba1c And Albumin Creatinine Ratio)
  7. (lactate Dehydrogenase (ldh) During Storage)
  8. (cd4+ T Lymphocyte As A Prognosis Predictor In Sepsis Patients)
  9. (angiotensin Ii On Adipocytes Culture Exposed With High Glucose)
  10. (the Panleucogating Method For Lymphocyte Cd4 Counting In Hiv Patients)
  11. (c3c Serum Complement And Blood T-cd4+ Lymphocyte)
  12. (cell Based Hemostatis – In Vivo)
  13. Neonatal Acute Myeloid Leukaemia

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