UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 17 / No. 1 / Published : 2010-01

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Original Article :

(urine eosinophyl in acute interstitial nephritis (ain)

Author :

  1. Felly G Sahureka*1
  2. Fitriani Mangarengi*2
  3. Uleng Bahrun*3
  1. Bag PK FK-UNHAS Makassar
  2. Bag PK FK-UNHAS Makassar
  3. Bag PK FK-UNHAS Makassar

Abstract :

  The diagnosis of AIN is performed by the evaluation of clinical signs and symptoms, laboratory tests, radio imaging and biopsy as a gold standard. In most cases, biopsy wasn’t performed because it is invasive for the patients, while the diagnosis  is just based on the clinical sign and symptom, and the immunosuppressive therapy is carried out only after the biopsy. Eosinophyluria found in the AIN patients is the parameter that can be measured non invasively, so that urine eosinophyl test was suggested for the diagnosis /early detection of AIN. That background cause us to analyze the urine eosinophyl count in suspected AIN patients. A cross sectional study was conducted from June to August 2008 on 50 suspect AIN patients and 50 of non AIN at the Laboratory of Clinical Pathology, dr.Wahidin Sudirohusodo Hospital Makassar. Urine eosinophyl test performed by Hansel method, samples were analyzed with SPSS for Windows version 12.0 using T test and Chi-square test. From 50 suspect AIN patients, they consist of 50%  men and 50% women with the age distribution between 4 and 72 years old. T test analysis showed that the urine eosinophyl count was higher in suspect AIN (2.820±1.955) compare with the non AIN (0.620±0,923), p < 0,001. The Chi-square test showed that there was a significant relation between eosinophyluria of the suspect AIN patients. That means there is a significantly relation between eosinphyiluria with the suspect AIN group, where was found the higher urine eosinophyl compare to those non AIN patients. From  this study so far, it can be suggested that urine eosinophyl test can be used for the diagnosis/early detection of AIN.   Diagnosis NIA ditetapkan berdasarkan gambaran klinis, laboratorium, pencitraan dan biopsi. Gold standar untuk mendiagnosis NIA adalah biopsi namun bersifat invasif sehingga menimbulkan trauma pada pasien. Di kebanyakan kasus, biopsi tidak dilakukan dan diagnosis ditetapkan atas dasar gejala dan perjalanan klinis, sementara terapi imunosupresif hanya diberikan setelah biopsi. Eosinofiluria yang sering ditemukan di pasien NIA merupakan parameter yang dapat diukur secara non invasif, sehingga Tes eosinofil urin disarankan untuk membantu mendiagnosis/deteksi dini NIA. Tujuan telitian ini, menganalisis jumlah eosinofil urin pasien suspek NIA sehingga dapat  diketahui apakah eosinofiluria dapat digunakan sebagai parameter penilaian untuk menetapkan diagnosis NIA. Penelitian dilakukan secara cross sectional di 50 pasien suspek NIA dan 50 pasien non NIA di Instalasi Laboratorium Patologi Klinik BLU RSUP dr. Wahidin Sudirohusodo Makassar selama periode Juni-Agustus 2008. Tes eosinofil urin dilakukan dengan metode Hansel, data dianalisis menggunakan SPSS for windows versi 12,0  dengan  uji T dan Chi-square. Dari 50 pasien suspek NIA didapatkan 25 pasien laki-laki dan 25 pasien perempuan, dengan distribusi umur antara 4-72 tahun. Uji T menunjukkan ada perbedaan bermakna antara hasil tes eosinofil urin suspek NIA dan non NIA (p<0,001), dimana eosinofil urin lebih tinggi di suspek NIA (2,820±1,955) dibandingkan non NIA (0,620±0,923)  dengan. Uji Chi-square menunjukkan ada hubungan yang bermakna antara kadar eosinofil urin dengan penderita suspek NIA (p<0,001). Sehingga dapat disimpulkan, kadar eosinofil urin berbeda bermakna antara penderita suspek NIA dan non NIA, dimana ditemukan eosinofil urin yang lebih tinggi di penderita suspek NIA. Dengan demikian tes eosinofil urin dapat dipakai sebagai tes non invasif untuk membantu menetapkan diagnosis/deteksi dini  NIA.

Keyword :

urine eosinophyl, acute interstitial nephritis,


References :

Baker RJ, Pusey CD,(2004) The changing profile of acute tubulointerstitial nephritis USA : Nephrol Dial transplant

Eknoyan G,(2004) Tubulointerstitial nephropathies in Goldman L, Ausiello D, eds London : Saunders Coy

Kodner CM, Kudrimoti A,(2003) Diagnosis and management of acute interstisiel nephritis USA : Am Fam Phys

Widiana IGR,(2006) Penyakit tubulointerstisial. Dalam Buku ajar ilmu penyakit dalam Jakarta : Pusat Penerbitan Departemen Ilmu Penyakit Dalam FKUI

Brent A. Alper Jr, MD. MPH,(2008) Emedicine from WebMD USA : Article Last Updates





Archive Article

Cover Media Content

Volume : 17 / No. : 1 / Pub. : 2010-01
  1. (urine Eosinophyl In Acute Interstitial Nephritis (ain)
  2. Methicillin Resistant On Staphylococcus Aureus At Hospital Ward
  3. The Validity Examination D-dimer Assay Between Immunofiltration Method And Immunoturbidimetric Method
  4. Plasma Secretory Phospholipase-a2 Activity Inthrombocytopenic Dengue Haemorrhagic Fever
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  6. Correlation Between Serum Neuron-specific Enolase And Glasgow Coma Scale In Traumatic Head Injury
  7. Cut Off Value Dengue Quantitative Ns1 Antigen As Predictor Severity Of Dengue Viral Infection In Children
  8. The Role Of γ-interferron Gene (ifng) Polymorphism In Phenotype Histology Lupus Nephritis
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  10. Flaming Cells In Multiple Myeloma

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