UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 15 / No. 3 / Published : 2009-07

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Original Article :

A retinoid acid receptor in acute promyelocytic leukemia auer rods

Author :

  1. Adi K. Aman*1
  2. Tonny*2
  1. Departemen Patologi Klinik FK USU/RSUP H. Adam Malik Medan
  2. Departemen Patologi Klinik FK USU/RSUP H. Adam Malik Medan

Abstract :

Acute Promyelocytic Leukemia (APL) is a subtype of AML with a defined clinical course and biology that is distinct from other forms of AML. The term M3-AML was assigned to the hyper granular promyelocytic leukaemia that is characterized by blast cells with azurophilic granules, bundles of auer rods and reniform or bilobed nucleus. Clinically, APL is related to disseminate intravascular coagulation and abnormal fibrinolysis. Cytogenetically, APL may cause translocation on the promyelocytic leukaemia (PML) gene, and chromosome 15 and with the retinoic acid receptor α (RARA) gene, on chromosome 17. The diagnosis of APL is shown by bone marrow morphologically The majority of cells in the bone marrow are abnormal, having some similarities with promyelocytes. The malignant cells bear numerous large granules and several auer rods. Aspirates of bone marrow are also taken for cytogenesis evaluation and for detecting the translocation. A twelve years girl was admitted to the hospital with haemorrhage from the gums during 5 day after extraction of a tooth. On physical examination there is no organomegaly shown. The laboratory examination found normocytic normochromic anaemia, leucopoenia and thrombocytopenia with 15% blast cell and 5% promyelocytes with multiple auer rods. The bone marrow aspirates showed predominant of promyelocyte cells (70%) with multiple auer rods.

Keyword :

APL, Auer rod, Promyelocytic leukaemia, retinoid acid receptor a,


References :

Soignet SL, Maslak PG,(2004) Acute Promyelocytic Leukemia Philadhelpia : Lippincott Williams and Wilkins





Archive Article

Cover Media Content

Volume : 15 / No. : 3 / Pub. : 2009-07
  1. Cd4 Cell Counts With Igm Herpes Simplex-type 2 In Hiv Patients
  2. The Transferrin Saturation Profile Among Anaemic Blood Donors
  3. Iron Deficiency Anemia Of Babies
  4. Patients’ Serum Protein Electrophoresis With Normal Serum Total Protein Level
  5. Inflammatory Marker Hs Crp With Hipertension
  6. Comparison Of Kalium Serum Level With Or Without Insulin Therapy At Type 2 Diabetic Mellitus Patiens
  7. Microalbuminuria Of Type 2 Dm Patients
  8. Analysis Of The Immunochromatography And Enzyme-linked Immunosorbent Assay Tests To Diagnose Helicobacter Pylori In Dyspepsia
  9. Soluble Transferrin Receptor Level In Human Immunodeficiency Virus/acquired Immunodeficiency Syndrome Patients With Anemia
  10. Comparison Of Specthrophotometer Method With Hemocue Method For Haemoglobin Measurement In Leucocytosis Sample
  11. Toll-like Receptor (tlr) And Natural Immunity
  12. A Retinoid Acid Receptor In Acute Promyelocytic Leukemia Auer Rods
  13. Errors During Clinical Laboratoric Procedures

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