UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 13 / No. 2 / Published : 2007-03

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Original Article :

Adult acute lymphoblastic leukemia with bilineage phenotipic (b and t-lymphoid)

Author :

  1. Maimun Z A*1
  2. Budiman -*2
  1. Laboratorium Patologi Klinik FK Unibraw/RSU Dr. Saiful Anwar
    Jl. JA Suprapto No. 2 Malang
  2. Laboratorium Patologi Klinik FK Unibraw/RSU Dr. Saiful Anwar Jl. JA Suprapto No. 2 Malang

Abstract :

In this report we describe a patient with adult acute lymphoblastic leukemia with bilineage phenotypic. �HewasfoundtohaveHe was found to have massive right pleural effusion with mediastinal shift to the contra lateral side. There was also a smaller left pleural effusion. He had multiple bilateral cervical lymphadenopathy, tense ascites and bilateral pedal oedema up to the shins. He was otherwise clinically stable. His full blood count on admission showed Hb of 11.4 g/dl, platelets of 59 X 109/L and WBC of 12.99 × 109/L with blasts of 26%. His renal function was normal with a creatinine of 107 micromoles/L. Bone marrow trephine biopsy showed features consistent with acute lymphoblast leukemia-L1. Flow cytrometry of his blood was suggestive of bilineage phenotypic acute lymphoblast leukaemia. It showed a single population of blasts (about 31%) which expressed cCD3+, CD4-, CD7+, CD5-, CD19+, CD34+, TdT+, cytoplasm IgM, CD79a+ and 30% are CD10+, and there was aberrant CD33+ expression with no evidence of MPO or CD117 expression. Cytogenesis of the bone marrow trephine biopsy showed numerical and structural abnormalities in nine out of the seventeen cells analysed. These abnormalities are 43~47,XY, add (1)(p34.2), add(2)(p13), i(17)(q10), +21[cp9].

Keyword :

Key words: adult ALL, bilineage phenotypic,


References :

Head DR,(2004) Classification and Differentiation of acute leukemias Philadhelpia : Lippincott Williams and Wilkins





Archive Article

Cover Media Content

Volume : 13 / No. : 2 / Pub. : 2007-03
  1. Features Of Igm – Igg Rapid Serological Test And Routine Hematology Analysis Of Dhf Patients
  2. Profile Of Cholesterol And Albumin Concentration And Urine Sediment Based On Nephrotic Syndrome Children
  3. Analysis Of Serum Albumin Level With Ratio De Ritis In Hepatitis B Patients
  4. Congenital Rubella Syndrome Based On Serologic And Rna Virus Examination
  5. Adult Acute Lymphoblastic Leukemia With Bilineage Phenotipic (b And T-lymphoid)
  6. The Diagnostic Value Of A Cassette Immunochromatographic Test As A Diagnostic And In Dhf Adult Patients
  7. Strategic Prioritization In Clinical Laboratory Services Using Sfas Technique By Means Of Swot Matrix
  8. Creatinine And Creatinine Clearance Value Of Leptospirosis Patients

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