UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 18 / No. 1 / Published : 2011-01

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Original Article :

Aerob microbes pattern and antimicrobial sensitivity of diabetic foot ulcer

Author :

  1. Liong Boy Kurniawan*1
  2. Tenri Esa*2
  3. Nurhayana Sennang*3
  1. Bag PK FK-UNHAS Makassar
  2. Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Hasanuddin, RS. Dadi, Makassar
  3. Bag PK FK-UNHAS Makassar

Abstract :

Diabetic foot ulcer is a common complication of diabetic disease which causes morbidity and foot amputation. One major pathogenesis is infection. Microbes which infect are varied. The use of inappropriate antimicrobials can or may cause drugs resistance. Data of microbes pattern and sensitivity test is important and may guide the clinician in giving the initial therapy. The aim of this retrospective study was to know the characteristics, microbial pattern, and the sensitivity to antimicrobial drugs of 31 diabetic foot ulcer patients who were hospitalized at Wahidin Sudirohusodo Hospital, Makassar in the period of January 2009 until June 2010. The study results showed the age mean was 54.06+ 12.4 years old, and the  onset of diabetes mellitus was 7.62+5.77 years. The common microbes were gram negative bacteria (73.52%) including Enterobacter agglomerans, Proteus mirabilis and Klebsiella pneumonia, while the most common gram positive microbe was Streptococcus sp. Gram positive microbes were sensitive to meropenem, ceforoxim and amoxilin, while Gram negative microbes were sensitive to meropenem. Based on this study, the researchers concluded that the most common microbes which infect the feet were gram negative microbes. Gram positive microbes were still sensitive to meropenem, ceforoxim and amoxilin. Gram negative microbes were sensitive to meropenem.       Tukak (ulkus) kaki diabetik merupakan hal yang umum dijumpai di penyakit diabetes dan sering menyebabkan kecacatan dan pengeratan (amputasi) kaki. Salah satu terjadinya penyakit ulkus utama kaki diabetik adalah akibat infeksi. Terdapat beragam kuman yang menginfeksi ulkus kaki diabetik. Penggunaan antimikroba yang tidak sesuai dapat menyebabkan resistensi kuman. Data pola dan kepekaan kuman penting dan membantu peklinik untuk mengobati awal penderita. Gambaran penelitian tinjauan ke belakang (retrospektif) bertujuan untuk mengetahui ciri 31 penderita ulkus kaki diabetik, jenis bakteri dan kepekaan kuman nanah  ulkus kaki penderita diabetik terhadap antibiotik di Rumah Sakit dr. Wahidin Sudirohusodo (RSWS) Makassar masa waktu Januari 2009 sampai Juni 2010. Telitian rerata umur penderita adalah 54,06+ 12,4 tahun, lama menderita diabetes mellitus (DM) adalah 7,62+5,77 tahun. Kuman terbanyak adalah Gram negatif (73,52%) yaitu Enterobacter agglomerans, Proteus mirabilis dan Klebsiella pneumonia, sedangkan kuman Gram positif terbanyak adalah Streptococcus sp. Kuman Gram positif peka terhadap meropenem, ceforoxim, dan amoxilin, sedangkan kuman Gram negatif peka terhadap meropenem. Kuman terbanyak menginfeksi adalah Gram negatif. Antimikroba Gram positif yang masih peka adalah  meropenem, ceforoxim dan amoxilin, sedangkan terhadap Gram negatif adalah meropenem.

Keyword :

Diabetic foot ulcer, microbes, antimicrobial sensitivity,


References :

Jeffcoate WJ, Harding KG,(2010) Diabetik Foot Ulcers USA : The Lancet Review

Singh D,(2006) Diabetik Foot: It’s Time to Share The Burden India : Calicut Medical J

Bowering CK,(2001) Diabetik Foot Ulcers Pathophysiology Assessment and Theraphy USA : Can Fam Phys

Adam JMF,(2005) Komplikasi Kronik Diabetik Masalah Utama Penderita Diabetes dan Upaya Pencegahan Jakarta : J Med Nusan Suplement

Frykberg RG, et al,(2000) Diabetik Foot Disorders A Clinical Practice Guideline USA : The J of Foot Ankl Surg Suplement





Archive Article

Cover Media Content

Volume : 18 / No. : 1 / Pub. : 2011-01
  1. Aerob Microbes Pattern And Antimicrobial Sensitivity Of Diabetic Foot Ulcer
  2. Plasma Levels Of Interleukin 10 (il-10) In Malaria And Anaemia
  3. Identification Of Cryptosporidiosis In Paediatric Hiv-infected Patients With Chronic Diarrhoea At Paediatric Gastro
  4. Immunoglobulin A In Dengue Hemorrhagic Fever
  5. (comparison Of Determination For Thyroxine With Enzyme Linked Immunofluorescent Assay (elfa) And Enzyme Linked Immunosorbant Assay (elisa)}
  6. Plasma Interleukin-10 And Cd4+ Lymphocyte-t In Hiv Infected Patients
  7. Detecting Fluoroquinolone Resistance Of Salmonella Sp Using Nalidixic Acid Succeptibility Test
  8. Phyllanthus Niruri L The Effects Of Extract On Cellular Immunity Mice
  9. Fitoestrogen Dalam Beberapa Daun Dan Buah
  10. Diagnostic Test Nt Pro Natriuretic Peptide (ntprobnp) On Congestive Heart Failure
  11. Human Immunodeficiency Virus (hiv) Infection In Babies And Children
  12. Decompensated Cirrhosis Hepatic In Children
  13. Human Resources Management In The Clinical Laboratory

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