UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 17 / No. 2 / Published : 2010-11

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Original Article :

Association between atypical depolarization on the cell-dyn 3200 and the presence of plasmodium spp in blood in the dr. soetomo hospital surabaya

Author :

  1. Esti Rohani*1
  2. J. Nugraha*2
  1. Departemen Patologi Klinik, Fakultas Kedokteran Universitas Airlangga/RSUD. Dr. Soetomo Surabaya
  2. Departemen Patologi Klinik, Fakultas Kedokteran Universitas Airlangga/RSUD. Dr. Soetomo Surabaya

Abstract :

Malaria is a parasitic disease worldwide with a high morbidity and mortality. A rapid and accurate methods is needed to detect the presence of malaria parasites in blood. A flagging system atypical depolarization (atypdep) on CBC result from Cell-Dyn 3200 instrument has been related with malaria infection. An observational cross sectional approach with a total of 48 samples were obtained from inpatients in the Dr. Soetomo Hospital Surabaya. Samples were screened with Cell-Dyn 3200 analyzer for CBC found atypdep flagging. The positive samples were later confirmed by microscopic to detect malaria parasites. From 48 samples with atypdep flagging, seven samples were positive of malaria in peripheral blood smear (13.1%). Most frequent atypdep flagging was seen in malignant disease (18.7), an approximately 54.6% of the sample is not accompanied by symptoms of fever. Lekositosis and anemia were found in each of 20 samples (41.6%) and thrombocytopenia in 33.3% of the samples. The presence of atypdep flagging does not necessarily indicate the existence of malaria infection or it could be said that atypdep flagging is not always associated with the presence of malaria infection. The usage of an atypdep flagging on Cell-Dyn instrument in non-endemic areas such as Surabaya is just an alert sign to evaluate the malaria infection rather than a screening method to detect malaria.

Keyword :

Plasmodium, atypical depolarization, cell-dyn 3200,


References :

Mendelow BV, Lyons C et all,(1999) Automated Malaria Detection by Depolarization of Lasar Light London : British Journal of Haematology





Archive Article

Cover Media Content

Volume : 17 / No. : 2 / Pub. : 2010-11
  1. The Diagnostic Value Of Heart-type Fatty Acid Binding Protein (h-fabp) Rapid Test Related To Cardiac Troponin I In Non St Elevation Myocardial Infarction (nstemi)
  2. The Creatinine Level And Potassium Serum In Patients With And Without Type Ii Diabetic
  3. Procalcitonin For The Differentiation Of Bacterial And Non Bacterial Infection
  4. Diagnosis Of Dengue Virus Infection With Iga Anti Dengue Rapid Tests
  5. The Platelet Aggregation Test As A Predictor Of Clinical Outcome In Acute Infarction Stroke
  6. Association Between Atypical Depolarization On The Cell-dyn 3200 And The Presence Of Plasmodium Spp In Blood In The Dr. Soetomo Hospital Surabaya
  7. The Correlation Between Thrombocyte And Cd4 Count In Hiv/aids Patients
  8. The Chemotherapy Effect In The Activity Of Transaminase Enzymes In Breast Cancer Patients
  9. Pathogenesis And Laboratory Examination Of Primary Myelofibrosis
  10. Star ()-flagged Leukocytosis As Indicator Of Interfering Factor In Automatic Hematology Analyzer
  11. (oral Administration Of Mycobacterium Tuberculosis 38-kilodalton Adhesin Protein Increases Macrophages And Lymphocytes In Intestinal Balb/c Mice)
  12. Diazo Test As A Screening Test Of Typhoid Fever A Practical Approach

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