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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 18 / No. 3 / Published : 2012-01

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Original Article :

Correlation of liver functions test, and the grade of dengue hemorrhagic fever in children

Author :

  1. Ani Kartini*1
  2. Mutmainnah*2
  3. Ibrahim Abdul Samad*3
  1. Bag PK FK-UNHAS Makassar
  2. Bag PK FK-UNHAS Makassar
  3. Bag PK FK-UNHAS Makassar

Abstract :

Dengue Hemorrhagic Fever (DHF) may result acute liver failure. Although these cases are rare but is more common in children, and early identification of these infections is important to reduce the morbidity as well as mortality. The aim of this study was to know the determinations and the correlation of liver functions with the grade of Dengue Hemorrhagic Fever in children. This study was conducted by cross sectional, using data from the medical records of DHF patients who had liver function tests (AST, ALT, PT, aPTT and albumin) in the Laboratory of Clinical Pathology Dr. Wahidin Sudirohusodo Hospital Makassar from the period of July 2008 to June 2010. AST, ALT and albumin were tested using Cobas Integra 400, PT and aPTT were tested using Humaclot VA, and the data were analyzed with Spearman correlation test.  There were fifty-five samples: 26 (47.3%) were males and 29 (52.7%) were females. We found 15 (27.3%) grade I, 13 (23.6%) grade II, 16(29.1%) grade III and 11 (20%) grade IV patients. In this study are found that AST and ALT increased and there is a tendency of extending aPTT value but there was no significant correlation with the grade of DHF. The mean of albumin was lower in grade IV, there was a significant correlation between albumin and the grade of DHF (r = -0.375, p <0.05). In conclusion, there was a significant correlation between albumin and the grade of DHF. It is suggested that the routine albumin examination in DHF patients should be carried on to know whether a prevention of complications is needed to reduce the possibility of mortality.     Demam Berdarah Dengue (DBD) dapat menyebabkan gagal hati akut, meskipun kasus ini jarang dilaporkan tetapi lebih banyak terjadi pada anak-anak, sehingga pengenalian dini infeksi ini penting untuk mengurangi angka kesakitan dan angka kematian. Tujuan penelitian adalah untuk mengetahui kenasaban fungsi hati terhadap derajat penyakit DBD. Penelitian dilakukan secara potong silang dengan mengambil data rekam medik pasien DBD yang memeriksakan uji fungsi hati (AST,ALT, PT, aPTT dan Albumin) di Laboratorium Patologi Klinik RS. Dr. Wahidin Sudirohusodo Makassar masa waktu Juli 2008 sampai Juni 2010. Pemeriksaan uji AST, ALT dan Albumin menggunakan Cobas Integra 400. Uji PT dan aPTT menggunakan Humaclot VA. Pada penelitian ini digunakan sebanyak 55 sampel, 26 orang (47,3%) laki-laki dan 29 (52,7%) perempuan. DBD derajat I 15 orang, derajat II 13 orang, derajat III 16 orang dan derajat IV 11 orang. Terdapat peningkatan aktifitas AST dan ALT dan pemanjangan aPTT, tetapi tidak bernasab dengan derajat DBD. Rerata Albumin semakin rendah pada derajat IV, dengan uji Spearman terdapat kenasaban yang bermakna antara kadar Albumin dan derajat DBD (r=-0.375, p< 0.05). Didasari penelitian ini dapat disimpulkan bahwa terdapat kenasaban yang bermakna antara Albumin dan derajat penyakit DBD, sehingga perlu diperiksa Albumin secara rutin bagi semua pasien DBD untuk mencegah komplikasi dan mengurangi kematian.

Keyword :

Dengue hemorrhagic fever, children, liver function test,


References :

  1. Siregar F.A, (2004). Epidemiologi dan Pemberantasan Demam Berdarah Dengue di Indonesia. Medan : Fakultas Kesehatan Masyarakat Universitas Sumatera Utara (USU)
  2. World Health Organization, (2002). Demam Berdarah Dengue, Diagnosis, Pengobatan, Pencegahan, dan Pengendalian. Jakarta : Penerbit EGC
  3. Suhendro dkk, (2006). Demam Berdarah Dengue dalam: Buku Ajar Ilmu Penyakit Dalam. Jakarta : Pusat Penerbitan Ilmu Penyakit Dalam FK-UI
  4. Djunaedi D, (2006). Demam Berdarah Epidemiologi, Imunopatologi, Patogenesis, Diagnosis dan Penatalaksanaannya. Malang : Penerbit Universitas Muhammadiyah Malang
  5. Sub Dinas P2PL, (2006). Laporan hasil kegiatan sub dinas P2PL. Dinas Kesehatan Prov. Sul-Sel. Makassar : Sub Dinas P2PL


   


Archive Article

Cover Media Content

Volume : 18 / No. : 3 / Pub. : 2012-01
  1. Prothrombin time and activated partial thromboplastin time test’s result using humaclot va and sysmex ca 500
  2. Association hla-drb1* and hla-dqb1* with serum igm-rf with rheumatoid arthritis
  3. Platelets of dengue hemorrhagic fever
  4. The diagnostic value of tb antigen using rapid test device (tb ag) for pulmonary tuberculosis
  5. Antimicrobial susceptibility test of pathogenic aerobic bacteria at the internal medicine ward
  6. Correlation of liver functions test, and the grade of dengue hemorrhagic fever in children
  7. Pulmonary cryptosporidiosis in tbc patients
  8. Mycobacterium tuberculosis and pcr
  9. Oral immunization with 38-kda adhesin protein of mycobacterium tuberculosis on cd8+ t cells in lung
  10. Thrombocytes count in acute coronary syndrome related to low molecular weight heparin (lmwh)}
  11. Acute fatty liver of pregnancy
  12. Cold agglutinins in a community acquired pneumonia patient