UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 21 / No. 1 / Published : 2014-01

Order : 2, and page :5 - 10

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Original Article :

Correlation plasma fibrinogen with intima-media thickness of carotid artery in diabetes mellitus

Author :

  1. Dwi Aryani*1
  2. Budi Mulyono*2
  3. Osman Sianipar*3
  1. Patologi Klinik FK UGM/RSUP Dr. Sardjito Yogyakarta
  2. Patologi Klinik FK UGM/RSUP Dr. Sardjito Yogyakarta
  3. Patologi Klinik FK UGM/RSUP Dr. Sardjito Yogyakarta

Abstract :

Diabetes mellitus is a global problem due to the increase of its prevalence, morbidity and mortality. Diabetes mellitus has chronic complications such as : micro vascular and macro vascular. The macro vascular complications reveal as atherosclerosis. The increase of carotid communist IMT was examined by using USG, which has become the standard for assessing atherosclerosis and recommended by the American Heart Association. Fibrinogen levels have a role in atherosclerosis. This study was design cross-sectionals to know the association between plasma fibrinogen with carotid communist IMT in patients with DM by special examination. The subjects were patients with DM coming to Dr DR. Sardjito Yogyakarta and fulfil the inclusion as well as the exclusion criteria. The examination of fibrinogen was carried out by Claus’s method. The result showed positive correlation between plasma fibrinogen with carotid communist IMT in type 2 diabetes mellitus, r = 0.36 and p = 0.021. There is also positive correlation between age and carotid IMT with r = 0.314 and p = 0.048. Diabetes melitus adalah masalah yang mendunia karena pasien yang mengidap semakin meningkat dan berangka kesakitan dan kematian yang tinggi. Diabetes melitus berkomplikasi kronik berupa mikrovaskular dan makrovaskular. Komplikasi makrovaskular berupa aterosklerosis. Peningkatan Intima-Media Thickness (IMT) arteri karotis komunis diperiksa dengan ultrasonografi telah menjadi bakuan untuk menilai aterosklerosis dan disarankan oleh American Heart Association. Kadar fibrinogen berperan dalam kejadian aterosklerosis. Rancangan penelitian adalah potong lintang yang bertujuan untuk mengetahui hubungan antara fibrinogen plasma dan IMT arteri karotis di DM. Subjek penelitian adalah pasien DM tipe 2 yang datang ke RSUP DR. Sardjito Yogyakarta dan memenuhi patokan kesertaan maupun tidak. Pemeriksaan fibrinogen dengan metode Clauss. Antara kadar fibrinogen plasma dan IMT karotis komunis terdapat kenasaban positif dengan r = 0,36 dan p = 0,021. Umur bernasab positif dengan IMT karotis komunis dengan r = 0,314 dan p = 0,048.

Keyword :

Diabetes mellitus, Atherosclerosis, Carotid IMT, Fibrinogen,


References :

Suyono S,(2009) Diabetes Melitus Di Indonesia No. 5, Hal:1874–78. : Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia

Wild S, Roglic G, Green A, Sicree R,(2004) Global Prevalence of Diabetes, Estimates for the year 2000 and projections for 2030 No.27, hal: 1047-1053 : Diabetes Care





Archive Article

Cover Media Content

Volume : 21 / No. : 1 / Pub. : 2014-01
  1. The Level Of Interleukin-6 Plasma In Diabetes Mellitus Patients With And Without Diabetic Retinopathy
  2. Correlation Plasma Fibrinogen With Intima-media Thickness Of Carotid Artery In Diabetes Mellitus
  3. Matrix Metalloproteinase-2 In Breast Cancer Metastastis
  4. Potassium In Multidrug Resistance Tuberculosis With Kanamycin
  5. Safe Blood And Voluntary Non-remunerated Blood Donors
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  17. Vitamin D Deficiency And Diseases
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  19. The Role For Clinical Pathologist In Hospital Accreditation

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