UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 19 / No. 1 / Published : 2012-01

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Original Article :

Curcuma zedoaria and morinda citrifolia as hepatoprotector against carbontetrachloride

Author :

  1. Suprapto Ma’at*1
  1. Departemen Patologi Klinik Fakultas Kedokteran Universitas Airlangga

Abstract :

Herbal remedies are prescribed for the treatment of various liver diseases including for Hepatoprotector purpose. The present study was aimed to investigate and to know the hepatoprotective activity of Curcuma zedoaria extract combined with Morinda citrifolia extract against carbon tetra chloride (CCl4) induced hepatotoxicity in rats. Liver functions were assessed by the determination of SGOT, SGPT, ALP, and bilirubin. The results of serum analysis suggest that the use of Curcuma zedoaria extract combined with Morinda citrifolia extract exhibited significant protective effect related to the hepatic damage in CCl4 induced hepatotoxicity model and further evidence of its hepatoprotective activity.     Obat herbal telah banyak diberikan untuk pengobatan berbagai macam penyakit hati termasuk sebagai hepatoprotektor. Penelitian ini dimaksudkan untuk menyelidiki khasiat dan mengetahui aktivitas hepatoprotektif gabungan sari kunyit putih/temulawak (Curcuma zedoaria) dan buah mengkudu (Morinda citrifolia) terhadap hepatotoksisitas tikus yang diimbas dengan karbontetraklorida. Fungsi hati diukur berdasarkan penentuan level SGOT, SGPT, ALP dan bilirubin. Hasil analisis serum membuktikan bahwa gabungan sari kunyit putih dan buah mengkudu menunjukkan ada pengaruh melindungi yang berarti dari kerusakan hati dalam model hepatotoksisitas  yang diimbas dengan CCl4 dan selanjutnya membuktikan bahwa gabungan sari tersebut memiliki aktivitas hepatoprotektif.

Keyword :

Curcuma zedoaria roscoe, morinda citrifolia L, carbon tetra chloride, Hepatoprotective,


References :

Clawson GA,(1989) Mechanisms of carbon tetrachloride hepatotoxicity USA : Pathol Immunopathol Res

Shiobara, Y., Y. Asakawa, et al,(1985) Curcumenone, curcumanolide A and curcumanolide B, three sesquiterpenoids from Curcuma zedoaria USA : Phytochemistry

3. Matsuda H, Nonimiya K, Morikawa T, Yoshikawa M,(1998) Inhibitory effect and action mechanism of sesquiterpene from zedoariae rhizoma on D-galactosamine/ lipopolysaccharide-induced liver injury Jepang : Bioorganic & Medicinal chemistry letter

Kim DI, Lee TK, Jang TH, Kim CH,(2005) The inhibitory effect of Korean herbal medicine, Zedoariae rhizoma, on growth of cultured human hepatic myofibroblast cells USA : Life Sci

5. Furusawa, E., Hirazumi, A., Story, S., Jensen, J,(2003) Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice’ USA : Phytother Res





Archive Article

Cover Media Content

Volume : 19 / No. : 1 / Pub. : 2012-01
  1. Pulmonary Cryptosporidiosis In Hiv And Aids
  2. Aerob Bacteria And Antimicrobial Susceptibility
  3. Plasma Volume And Factor Viii In Cryoprecipitated
  4. Comparation Measurement Triglycerides, Glycerol Blanking And Non Glycerol Blanking In Liver Cirrhosis
  5. The Residue Of Leukocyte In Thrombocyte Concentrate
  6. Antimicrobial Sensitivity Of Blood Culture In Neonatal Sepsis
  7. Neutrophils Lymphocyte Ratio In Acute Appendicitis
  8. Curcuma Zedoaria And Morinda Citrifolia As Hepatoprotector Against Carbontetrachloride
  9. Mean Platelet Volume In Stroke
  10. Dengue Serotypes Distribution In Surabaya In The Year 2012
  11. M.tuberculosis In Innate Immunity Associated With The Receptors
  12. Ovarian Dysgerminomas Cancer
  13. Information System In Laboratory Services

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