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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 17 / No. 1 / Published : 2010-01

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Original Article :

Dengue virus profile in surabaya from 2008-2009

Author :

  1. Aryati*1
  2. Puspa Wardhani*2
  1. Bag PK FK-UNAIR/RSU Dr. Soetomo Surabaya
  2. Bag PK FK-UNAIR/RSU Dr. Soetomo Surabaya

Abstract :

  Four serotypes of dengue viruses (DENV) 1-4 are mosquito-borne human pathogens that cause widespread epidemics with considerable morbidity and mortality. The aim of this study was to evaluate the dengue serotypes profile, which were circulating in Surabaya. This research has been carried out consisting of 360 samples from patients with dengue virus infections, according the World Health Organization (WHO) criteria. These sera were collected from patients Dr Soetomo Hospital and private laboratory in Surabaya from 2008-2009. From 360 samples, 68 samples (18.9%) were undifferentiated fever, 53 samples (14.7%) were dengue fever, 239 samples (66.4%) were dengue hemorrhagic fever. From 58 Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) samples, 25 samples (43%) were positive, consisting of 52% DEN-2, 20% DEN-1, 16% DEN-3 and 12% DEN-4. These results showed that four serotypes are circulating in Indonesia, dominated by DEN-2, followed by DEN-1, DEN-3 and DEN-4.       Keempat serotipe virus dengue (DENV) 1-4 merupakan patogen manusia yang diperantarai oleh nyamuk. Penyebarannya secara luas dapat menyebabkan kesakitan dan kematian. Tujuan penelitian ini untuk mengevaluasi profil serotip dengue yang bersirkulasi di Surabaya. Penelitian ini terdiri dari 360 sampel penderita infeksi virus dengue yang memenuhi kriteria WHO. Sera dikumpulkan dari pasien RSUD. Dr. Soetomo dan laboratorium swasta di Surabaya pada tahun 2008-2009. Dari 360 sampel, 68 sampel (18,9%) merupakan demam nonspesifik, 53 sampel (14,7%) demam dengue dan 293 sampel (66,4%) demam berdarah dengue. Dari 58 sampel yang diperiksa menggunakan RT-PCR (reserve transcriptase polymerase chain reaction), 25 sampel (43%) memberikan hasil positif, terdiri dari 52% DEN-2, 20% DEN-1, 16% DEN-3 dan12% DEN-4 Hasil ini menunjukan bahwa dari keempat serotipe yang bersirkulasi di Indonesia, didominasi oeh DEN-2, diikuti oleh DEN-1, DEN-3 dan DEN-4.

Keyword :

virus dengue profile, profil virus dengue,


References :

  1. Dinas Kesehatan Propinsi Jawa Timur, (2008). Situasi Penyakit DBD Propinsi Jatim dan Kebijakan Program P2 DBD. Surabaya : Dinas Kesehatan Propinsi Jawa Timur
  2. Soegijanto S, (2004). Demam Berdarah Dengue Surabaya. Surabaya : Airlangga University Press
  3. Leitmayer KC, (1999). Dengue virus structural differences that correlate with pathogenesis. USA : Journal of Virology
  4. Messer WB, Gubler DJ, Harris E, Sivananthan K, de Silva AM, (2004). Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus. USA : Emerg Infect Dis (serial online)
  5. Watts DM, Porter KR, Putvatana P, Vasquez B, Calampa C, Hayes CG,. Halstead SB, (1999). Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever. USA : Lancet


   


Archive Article

Cover Media Content

Volume : 17 / No. : 1 / Pub. : 2010-01
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