UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 12 / No. 1 / Published : 2005-11

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Original Article :

Determination of iron deficiency in chronic disease anemia by the role of stfr-f index

Author :

  1. A. Muhammad*1
  2. O. Sianipar*2
  1. Bagian Patologi Klinik Fakultas Kedokteran Universitas Gadjah Mada /RS Dr. Sardjito, Yogyakarta
  2. Bagian Patologi Klinik Fakultas Kedokteran Universitas Gadjah Mada /RS Dr. Sardjito, Yogyakarta

Abstract :

The highest prevalence of nutrition problem due to nutrition deficiency is iron deficiency. Chronic disease anemia often occurs coincide with iron deficiency and both show of low iron serum appearance. Difficulty occurs when iron deficiency determined in chronic disease anemia by routine parameters. Bone marrow stainning can indicate iron store, but it is invasive. Therefore it needs another more practical parameter that has higher diagnostic value. To know the more practical parameter that can determine iron de ficiency in chronic disease anemia . Ferritin serum indicates iron store in the body, whereas transferin receptor indicates functional of iron uptake in the erythrocyte. Changes of ferritin level due to inflammation process are varies. Recent evidence shows different changes of transferin receptor between iron deficiency anemia and those in chronic disease anemia. In chronic disease anemia, receptor transferin level increase but not as high as in those who suffer from pure iron deficiency anemia. Studies on groups of iron deficiency anemia, iron deficiency with acute inflammation, chronic disease anemia and healthy control population showed signi ficance differences of receptor transferin among them. sTrF -R index is an index derived from the calculation of transferin receptor level divided by logarithmic of the f erritin level. The usage of sTfR -F index indicates more significance difference as compared to transferin receptor. Its sensitivity and specificity increase when it is applied to diagnose iron deficiency in elderly group. sTfR-F index is more sensitive and specific for the determination of iron deficiency in chronic disease anemia

Keyword :

iron deficiency, chronic disease anemia, sTfR-F index,


References :

Dallman,(1987) Iron Defisiensi and related nutritional
anemias. In Hematology of infancy and childhood. 3rd edition. Nathan DG, Oski FA eds. Philadelphia: WB Saunders Company - : -

Gladder,(2004) The Anemias. In Nelson text book Pediatric.
17th edition. Behrman : Kliegman and Jenson eds. Saunders

Suharyo,(1999) Pemetaan anemia pada ibu dan anak balita
di Jawa Tengah. Lembaga Penelitian Kesehatan. - : -

Lee,(1983) The Anemia of chronic disorders. Semin
Haematology (20) - : -

Lee,(1983) The anemia of chronic disorders. In Lee GR
eds Wintrobe’s Clinical Haematology 9th edition. Malvern,
Pennsylvania: Lea and Ferbriger - : -

Jandl,(1991) Hypochromic anemias and disorders of iron
metabolism. In Jandl JH eds Blood Phatophysiology 1st edition. Boston : Blackwell Scientific Publication

Cartwright,(1996) The anemia of chronic disorders. Semin Hematology - : -

Wirawan,(1995) Diagnosis Anemia. MKI. 45 (12) - : -

Walmsl



Archive Article

Cover Media Content

Volume : 12 / No. : 1 / Pub. : 2005-11
  1. The Microbiology Of Upper Respiratory Tract Infection On Surabaya’s Pilgrim Group 2004
  2. Determination Of Iron Deficiency In Chronic Disease Anemia By The Role Of Stfr-f Index
  3. Molecular Pathology Of Cerebrovascular Atherosclerosis
  4. Hypocolemic Periodic Paralysis
  5. Widal Tube Test Capability Using Imported Antigens And Local Antigens
  6. Increasing Quality Of Hospital Clinical Laboratory
  7. Cushing Syndrome In Pregnancy
  8. Hepatotoxic Effect Of Antituberculose Drugs On Aspartate Amino Transferase And Alanine Amino Transferase Levels In Tuberculosis Patients

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