UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 14 / No. 1 / Published : 2007-11

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Original Article :

Diagnostic value of a quantitative immunochromatography assay for troponin i

Author :

  1. Siti Fatonah*1
  2. Anik Widijanti*2
  3. Tinny Endang Hernowati*3
  1. Laboratory of Clinical Pathology Medical Faculty of Brawijaya University/ Dr. Saiful Anwar General Hospital Malang
  2. Laboratory of Clinical Pathology Medical Faculty of Brawijaya University/ Dr. Saiful Anwar General Hospital Malang
  3. Laboratory of Clinical Pathology Medical Faculty of Brawijaya University/ Dr. Saiful Anwar General Hospital Malang

Abstract :

Cardiac troponins are the most sensitive and specific biochemical markers of myocardial damage but there is no standardization of WHO for cardiac troponin I, resulting in a variability for diagnostic value. It is necessary to determine diagnostic value for a new kit of troponin I. To evaluate a new quantitative immunochromatography assay for troponin I at a various cut off level. A cross sectional study was conducted in 64 patients with acute myocardial infarction (AMI) and 55 non-AMI as control from February to September 2007. The level of cardiac troponin I (cTnI) was measured and determined it diagnostic value at a various cut off level. The sensitivity, specificity, PPV and NPV of this assay were 91%, 91%, 92% and 89% at cut off level of 1,0 ng/ml (according to the kit), respectively. The cut off of cTnI were divided into five levels: 0.8, 1.0, 1.2, 1.5, and 2.0 with the area under curve were 0.923, 0.908, 0.912, and 0.897, respectively. The sensitivity were 94%, 91%, 86%, 81% and 72%, respectively, the specificity were 91%, 91%, 96%, 98% and 98%, respectively. This rapid diagnostic test is sensitive and specific to diagnose an acute coronary syndromes.

Keyword :

sensitivity, specificity, AMI, a quantitative cTnI assay,


References :

Jean-Claude Henquin,(2005) Cell Biology of Insulin Secretion New York : Lippincott Williams and Wilkins





Archive Article

Cover Media Content

Volume : 14 / No. : 1 / Pub. : 2007-11
  1. Conversion Of Afb Sputum Between Standard In 1st Category Group With High Dose Rifampicin Of Antituberculose Therapy
  2. The Correlation Between Fibrinogen And Concentration Microalbuminuria In Type 2 Diabetic Patients
  3. Diagnostic Value Of A Quantitative Immunochromatography Assay For Troponin I
  4. The Effect Of Calorie Restriction To Serum Hydrogen Peroxide Level And Glucose Blood Level In Old Mice
  5. Erythropoietin Physiology, Clinical, And Laboratory Aspect
  6. Dic/disseminated Intravascular Coagulation Caused By Venom Snake Bite
  7. The Level Of N Terminal-pro Brain Natriuretic Peptide In Hypertensive Heart Disease Patients
  8. Satisfaction Of Internal Customer

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