UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 14 / No. 3 / Published : 2008-07

Related with : Scholar   Yahoo!   Bing

Original Article :

Evaluation of immunochromatography method for detection of antibody to tuberculosis antigen in lung tuberculosis patients

Author :

  1. Kadek Mulyantari*1
  2. Aryati*2
  3. M.Y. Probohoesodo*3
  1. Departemen Patologi Klinik Fakultas Kedokteran Universitas Airlangga-RSU Dr. Soetomo Surabaya Jl. Mayjend Prof. Dr. Moestopo 6-8, Surabaya
  2. Departemen Patologi Klinik Fakultas Kedokteran Universitas Airlangga-RSU Dr. Soetomo Surabaya Jl. Mayjend Prof. Dr. Moestopo 6-8, Surabaya
  3. Departemen Patologi Klinik Fakultas Kedokteran Universitas Airlangga-RSU Dr. Soetomo Surabaya Jl. Mayjend Prof. Dr. Moestopo 6-8, Surabaya

Abstract :

The gold standard for TB still has some drawbacks, such as a long duration for culture examination and the rolated facilities are not always available in all laboratories. One of methods in diagnosing tuberculosis infection is by immunochromatography (ICT). MYCOTEC TB xp (recombinant) is one of serologic tests using immunochromatography principle. MYCOTEC TB xp uses recombinant antigens 38 kDa, 16 kDa, 6 kDa and Early Secreted Antigen Target (ESAT-6). This method is expected so far diagnose TB in a short time and has a high accuracy. Evaluating the immunochromatography method in detecting antibody by tuberculosis antigen in lung TB patients as will those with nonTB lung disease (lung tumor, bronchial asthma, pneumonia, chronic obstructive lungdisease). Serum samples of 30 TB patients in BP4/Karang Tembok Hospital Surabaya and 30 non TB patients in the Dr. Soetomo Hospital Surabaya. Detection of antibody to tuberculosis antigen was done with MYCOTEC TB xp. In this study found is prond 30 TB patients using MYCOTEC TB xp was positive in 23 samples and negative in 7 samples. From the 30 nonTB patients MYCOTEC TB xp was positive in 4 samples and negative in 26 samples. It can be uncloaded so far that the diagnostic sensitivity of MYCOTEC TB xp was 76.7% (23/30) and diagnostic specificity was 86.7% (26/30). MYCOTEC TB xp has an intermediate diagnostic sensitivity of 76.7% and a high diagnostic specificity of 86.7%.

Keyword :

Tuberculosis, ICT MYCOTEC TB xp, validity,


References :

Pradjoko I,(2006) Prosedur diagnostik dan tindakan pada tuberkulosis paru Surabaya : TCD UNAIR





Archive Article

Cover Media Content

Volume : 14 / No. : 3 / Pub. : 2008-07
  1. Cd4 Examination And Its Correlation With Hiv Diseases Stadium Of Patients
  2. Lactic Acid Profile In Controlled And Uncontrolled Diabetes Mellitus Patients
  3. Ldl Related Risk Markers For Coronary Heart Disease
  4. Evaluation Of Sensitivity And Specificity Of Troponin I And Troponin T As Cardiac Biochemical Markers In The Early Diagnosis Of Acute Myocardial Infarction (ami)
  5. Rapid Test For Igm Antibodies Salmonella Typhi Of Typhoid Fever
  6. The Immunosupression Of Renal Transplantation) (part Ii
  7. The Corelation Between Leukemia Plasma Cell And Myelofibrosis
  8. Evaluation Of Immunochromatography Method For Detection Of Antibody To Tuberculosis Antigen In Lung Tuberculosis Patients
  9. Laboratory Information System Self Building

Information CPML