UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 19 / No. 2 / Published : 2013-01

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Original Article :

Hairy cell leukaemia

Author :

  1. Reini Meilani Isbach*1
  2. Agus Alim Abdullah*2
  3. Mansyur Arif*3
  1. Bag PK FK-UNHAS Makassar
  2. Bag PK FK-UNHAS Makassar
  3. Bag PK FK-UNHAS Makassar

Abstract :

Hairy cell leukaemia (HCL) is a neoplastic disorder of B lymphocytes originally described by Bouroncle et al. in 1958. HCL clinical manifestations varies, generally characterized by various degrees of splenomegaly, pancytopenia, or emphasis only on the two cell lines (bisitopenia), with the hairy cells in varying amounts in the peripheral blood smear and bone marrow. HCL is a very rare case, there are only about 2% of all leukaemias more frequently in men than women (4:1) with the average age of disease onset between 50-55 years. The etiology of HCL is still not known. A case of HCL Leukaemia in a female patient, aged 55 years is reported which was a rare case. HCL diagnosis in this patient was based on the clinical manifestation (splenomegaly), and laboratory results (bisitopenia, neutropenia and monositopenia) and about 80% hairy cells were found in peripheral blood smears. Definite diagnosis of HCL should be made by bone marrow examination, immunophenotyping and cytogenesis.   Hairy cell leukaemia (HCL) merupakan kelainan neoplastik limfosit B tertentu yang awalnya digambarkan oleh Bouroncle et al. pada tahun 1958.1 Manifestasi klinis HCL beragam, umumnya ditandai dengan pembesaran limpa (splenomegali) dalam berbagai derajat, pansitopenia atau penekanan hanya di dua baris sel (bisitopenia), dengan sel berambut dalam jumlah yang beragam di hapusan darah tepi dan sumsum tulang. Kejadian HCL sangat jarang, jumlahnya hanya sekitar 2% dari seluruh leukemia dan ditemukan lebih sering di laki-laki dibandingkan perempuan (4:1) dengan usia rerata pasien/penderita antara 50-55 tahun. Penyebab HCL masih belum diketahui dengan pasti. Dalam artikel ini dilaporkan satu kasus yang diderita pasien perempuan, usia 55 tahun, yaitu leukemia sel berambut yang merupakan kasus jarang. Diagnosis HCL di pasien ini berdasarkan manifestasi klinis splenomegali, dan hasil periksaan laboratorik yaitu bisitopenia, neutropenia dan monositopenia serta gambaran sel berambut yang khas sekitar 80% di hapusan darah tepi. Diagnosis pasti HCL ditetapkan melalui pemeriksaan aspirasi sumsum tulang, imunofenotiping dan sitogenetik.

Keyword :

Hairy cell leukaemia, peripheral blood smears,


References :

Johnston, J.B,(2004) Hairy Cell Leukemia Philadelphia : Lippincott Williams & Wilkins

Saven, A,(2006) Hairy Cell Leukemia USA : The Mc.Graw-Hill Company

Besa, E.C., Krishnan, K,(2011) Hairy Cell Leukemia. Medscape reference USA : emedicine.medscape.com/article/200580-clinical

Hutchinson, R.E., Abraham, N.Z,(2007) Hairy Cell Leukemia. Precursor (Lymphoblastic) B and T Cell Neoplasms. Leucocytic Disorders USA : Saunders Elsevier

Czader, M,(2007) Hairy Cell Leukemia. Mature Lymphoid Neoplasms USA : Saunders Elsevier





Archive Article

Cover Media Content

Volume : 19 / No. : 2 / Pub. : 2013-01
  1. Clinical Manifestion Sepsis And Nitric Oxide Level On Mice Induced By Lipopolysaccharide
  2. Gandarusa (justicia Gendarussa Burm.f.) Water And Expression Of Hyaluronidase Gene By Pcr Analysis
  3. Proteinuria In Stroke With And Without Diabetic
  4. The Stewart’s Approach In Blood Ph Underlying Metabolic Acidosis
  5. Microbes And Antimicrobial Sensitivity In Open Fracture
  6. Katekin From Green Tea Leaves (camellia Sinensis) To Malondialdehyde (mda) And Super Oxide Dismutase (sod)
  7. Procalcitonin And Interleukin-6 In Sepsis Systemic Inflammatory Response Syndrome (sirs)
  8. Gram Negative And Gram Positive Aerobic Bacteria Identification Using Conventional And Automatic Method
  9. Immature Platelet Fraction (ipf) And Thrombopoietin In Liver Cirrhosis
  10. Eosinopenia And Procalcitonin In Sepsis
  11. C-x-c Receptor 4 (cxcr4) In Metastasis Of Breast Cancer
  12. Hairy Cell Leukaemia

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