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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 14 / No. 3 / Published : 2008-07

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Original Article :

Lactic acid profile in controlled and uncontrolled diabetes mellitus patients

Author :

  1. Laily Indrayanti*1
  2. Harjo Mulyono*2
  1. Departemen/SMF Patologi Klinik Fakultas Kedokteran Universitas Gadjah Mada Yogyakarta
  2. Departemen/SMF Patologi Klinik Fakultas Kedokteran Universitas Gadjah Mada Yogyakarta

Abstract :

Lactic acid is an intermediate product of carbohydrate metabolism. Increment of plasma lactic acid level usually correlated with aerobic metabolism defect which caused by hypoperfusion or hypoxia, that can be happened in DM (Diabetes Mellitus) patients. Diabetes Mellitus is a risk factor of lactic acidosis. Determination of glycated Hb (HbA1c) is a parameter to monitor the blood glucose. The aim of this study is to compare the mean lactic acid level between uncontrolled and controlled DM) patients and their correlation between lactic acid and HbA1c level. The research carried out by cross sectional study which was done at the Clinical Pathology Laboratory of Sardjito Hospital between September–October 2007. Inclusion criteria of samples were diabetic patients who had HbA1c examination. Statistical analysis was done by independent t test and Pearson correlation test. Twenty one patients were included in this research. They were divided into two (2) groups, group I are those who had HbA1c ≤ 7%, they consist of 10 patients, group II are patients who had HbA1c ≥ 7.1%, they consist 11 patients. The mean of lactic acid of group I was 1.85 mmol/L and group II was 1.74 mmol/L(p = 0.574). There wasn’t any significant correlation between HbA1c level and lactic acid. (r = -0.179, p = 0.437). The mean of lactic acid level in uncontrolled DM was lower than the controlled one but not significant, and there was no significant correlation between HbA1c level and lactic acid. It is suggested to continue this study but with larger sample to know the correlation between lactic acid and HbA1c in DM patients who had metformin therapy.

Keyword :

Lactic acid, HbA1c, diabetes mellitus,


References :

  1. Soewondo P, Hendarto H, (2006). Buku ajar penyakit dalam. Jakarta : Pusat penerbitan dep ilmu penyakit dalam FK UI


   


Archive Article

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Volume : 14 / No. : 3 / Pub. : 2008-07
  1. Cd4 examination and its correlation with hiv diseases stadium of patients
  2. Lactic acid profile in controlled and uncontrolled diabetes mellitus patients
  3. Ldl related risk markers for coronary heart disease
  4. Evaluation of sensitivity and specificity of troponin i and troponin t as cardiac biochemical markers in the early diagnosis of acute myocardial infarction (ami)
  5. Rapid test for igm antibodies salmonella typhi of typhoid fever
  6. The immunosupression of renal transplantation) (part ii
  7. The corelation between leukemia plasma cell and myelofibrosis
  8. Evaluation of immunochromatography method for detection of antibody to tuberculosis antigen in lung tuberculosis patients
  9. Laboratory information system self building