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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 14 / No. 3 / Published : 2008-07

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Original Article :

Ldl related risk markers for coronary heart disease

Author :

  1. Adi Priyana*1
  1. Departemen Patologi Klinik Fakultas Kedokteran Univ. Trisakti, Jakarta Alamat rumah: Jl. Kemanggisan utama III no. 6, Jakarta barat (11480), ������

Abstract :

Atherosclerosis is the most common cause of coronary heart disease (CHD), and it is still the primary cause of death in Indonesia and most industrialized countries. The conventional risk factor for atherosclerosis and CHD are diabetes mellitus, hypertension, dyslipidemia and smoking. On the other hand, Lp (a), homocystein and small dense LDL (sd-LDL) have been considered as novel risk factors for CHD. Low of high density lipoprotein (HDL), high of low density cholesterol (LDL-c) and high homocystein as part of dyslipidemia, has been considered as independent risk factor for CHD.The principal objective of the present study was to compare between HDL-c, Lp (a), and sd-LDL and homocystein as a risk marker of CHD. The study subject were divided into two groups, risk group consist of 94 subjects who had > 2 CHD risk factors and control group recruited 49 subject who had no CHD risk factors. Both groups had fasted for 10-12 hours before their sera were collected. The sera were examined for HDL-c, Lp (a), sd-LDL and homocystein. Four alternative multivariate models were compared: sd-LDL, sd-LDL + HDL-c, sd-LDL, HDL-c + Lp (a) and sd-LDL, HDL-c + sd-LDL + Lp (a) + homocystein. Result of this study showed that the sd-LDL had the most significant and accurate as risk marker for CHD. Lp (a), HDL-c and homocystein were less accurate if used as risk marker for CHD compare with sd-LDL. Small dense LDL is an accurate risk marker for CHD. Further study must be done using larger sample size of CHD subjects with similar age between risk and control groups.

Keyword :

coronary heart disease, risk marker (LDL cholesterol, Lp (a), homocystein and small dense LDL),


References :

  1. Greenberg RS, Daniels SR, et all, (2001). Diagnostic testing. New York : Lange Medical Book


   


Archive Article

Cover Media Content

Volume : 14 / No. : 3 / Pub. : 2008-07
  1. Cd4 examination and its correlation with hiv diseases stadium of patients
  2. Lactic acid profile in controlled and uncontrolled diabetes mellitus patients
  3. Ldl related risk markers for coronary heart disease
  4. Evaluation of sensitivity and specificity of troponin i and troponin t as cardiac biochemical markers in the early diagnosis of acute myocardial infarction (ami)
  5. Rapid test for igm antibodies salmonella typhi of typhoid fever
  6. The immunosupression of renal transplantation) (part ii
  7. The corelation between leukemia plasma cell and myelofibrosis
  8. Evaluation of immunochromatography method for detection of antibody to tuberculosis antigen in lung tuberculosis patients
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