UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 13 / No. 1 / Published : 2006-11

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Original Article :

Limited systemic sclerosis in a young boy

Author :

  1. Magdalena Tobing*1
  2. Siswanto Darmadi*2
  3. Yuliasih*3
  1. Bagian/Lab Patologi Klinik FK. UNAIR/RSU Dr. Soetomo
  2. Bagian/Lab Patologi Klinik FK. UNAIR/RSU Dr. Soetomo
  3. Bag. Penyakit Dalam (Divisi Rematologi) RSU Dr. Soetomo

Abstract :

Systemic Sclerosis is a chronic disorder characterized by diffuse fibrosis of the skin and internal organs. The cause of systemic sclerosis is unknown, but immune responses against unknown antigens have been implicated. Symptoms usually appear in the third to fifth decades, and women are affected three times more frequent than men. A 13 year old boy presented with hardening of left leg skin since 1 year before admittance. He was unable to both hands. The laboratory results showed slighty decreased hemoglobin, normal leucocytes and platelets, increased ESR, normal kidney and liver function tests, positive ANA test (weak), negative ENA and anti Scl-70. Other examination results showed normal X-Ray, Esophagogram, Schirmer test. Thyroid function test showed an euthyroid state. Systemic Sclerosis is established based on history of illness, physical examination and laboratory tests. ESR and CRP are increased in systemic sclerosis. Anemia in scleroderma can be due to various causes such as chronic disease, iron deficiency by gastrointestinal bleeding, B12 deficiency and folic acid deficiency. ANA test (IIF Hep-2) is positive in 60 –90%. Specific autoantibodies are Scl-70 and anticentromer. The anti Scl-70 can be used for prognosis.

Keyword :

Systemic Sclerosis, ANA test, ENA test,


References :

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Setyohadi B,(2000) Sklerosis Sistemik Dalam Noer HMS, Waspadji S, Rachman AM dkk (eds). Buku ajar Ilmu Penyakit Dalam edisi ketiga Jakarta : FKUI

Black,(2002) Scleroderma and fasciitis in childhood. Up To Date,10 (2) - : -

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Archive Article

Cover Media Content

Volume : 13 / No. : 1 / Pub. : 2006-11
  1. Levels Of B-hcg Among Patients With Hydatiform Mole Before And After Curettage
  2. Colony Count Candida Albicans Of Stool In Autism Spectrum Disorders
  3. The Comparison Of Wet Mount And Gram Stain Method For Vaginal Smear In Bacterial Vaginosis
  4. Microbial Patterns Based On Type Of Spesimens And Its Sensitivity To Antimicrobial Drugs
  5. The Value Of Sdldl Of Youngsters And Its Correlation With Other Lipids
  6. Lipid Profile In Type 2 Diabetic Mellitus Patient’s
  7. Pathogenesis And Diagnostics Factors Of Von Willebrand Disease
  8. Limited Systemic Sclerosis In A Young Boy
  9. The Correlation Between Fecal Occult Blood Test Using Anti-human Hemoglobin And Microscopic Examination
  10. Advantage And Disadvantage Of Quality Assurance Based On Point Of Care Testing/poct

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