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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 21 / No. 2 / Published : 2015-03

TOC : 14, and page :179 - 182

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Original Article :

Lipoprotein(a) in acute coronary syndrome

Author :

  1. Ira Puspitawati*1
  2. Setyawati*2
  3. Dyah Wulan Anggrahini*3
  4. Diah Saraswati*4
  5. Aisyah ratna Yuniarti*5
  1. Bagian Patologi Klinik FK UGM Yogyakarta
  2. Bagian Patologi Klinik FK UGM Yogyakarta
  3. Bagian Kardiologi dan Kedokteran Vaskuler FK UGM Yogyakarta
  4. Pendidikan Dokter FK UGM Yogyakarta
  5. Pendidikan Dokter FK UGM Yogyakarta

Abstract :

One of the risk factors of Acute Coronary Syndrome (ACS) still controversial is Lipoprotein(a). Lp(a) is one of the lipid components highly homologous to plasminogen and which may compete with it in the fibrinolytic pathway and has an atherogenic effect. Prior to the study many variaties in results have been shown. These variations are related to different population and ethnics, thus, the researchers were triggered to investigate the role of Lp(a) on the ACS in the Indonesian population. This case control study was conducted at the Sardjito General Hospital, Yogyakarta, Indonesia consisting of 40 participants in ACS as the case group and other 40 persons suffering from Stable Angina Pectoris (SAP) as a control group. This study lasted from May−December 2011. The Lp(a) was measured using turbidimetric immunoassay method while other laboratory results were obtained from the medical records. The results of this study showed that high Lp(a) level (more than 30 mg/dL) was the risk factor of ACS (RR=2.818, CI: 1.069–7.426). There was no difference of the baseline characteristics such as: the history of hypertension, diabetes mellitus, smoking, as well as in other laboratory parameters such as: lipid profile, hemoglobine and uric acid level in the case as well as the control group. Significant differences were found in leucocyte number, creatinine and blood glucose level. The median level of those parameters was found higher in the case group. Salah satu faktor kebahayaan Sindroma Koroner Akut (SKA) yang masih menjadi perdebatan adalah Lipoprotein(a), merupakan salah satu komponen lipid yang memiliki struktur menyerupai plasminogen serta memiliki sifat aterogenik. Penelitian sebelumnya masih menunjukkan hasil yang beragam. Ragaman ini terkait pula oleh keberadaan perbedaan suku dan keturunan. Berdasarkan fakta tersebut peneliti tertarik untuk mengetahui peran Lp(a) yang berkaitan dengan kejadian SKA dengan menelitinya. Penelitian ini berancangan kasus pembanding dengan subjek penelitian adalah pasien SKA yang dirawat di ICCU RSUP DR. Sardjito Yogyakarta dan yang pembanding adalah pasien dengan angina pektoris stabil. Penelitian ini melibatkan 40 subjek kasus dan 40 pembanding dan berlangsung antara bulan Mei−Desember 2011. Kadar Lp(a) diukur dengan metode immunoturbidimetry dan data lain diambil dari rekam medis. Hasil meneliti ini menunjukkan bahwa Lp(a) (lebih dari 30 mg/dL) terbukti merupakan faktor kebahayaan SKA dengan RR=2,818, CI (1,069–7,426) antara subjek kasus dan pembanding terhadap beberapa ciri dasar seperti: faktor kebahayaan hipertensi, penyakit Diabetes Melitus (DM), merokok, serta tolok ukur laboratorik profil lipid, hemoglobin, asam urat tidak didapatkan perbedaan yang bermakna. Perbedaan yang bermakna didapatkan di angka leukosit, kreatinin dan glukosa darah. Nilai median ketiga tolok ukur tersebut lebih besar daripada kelompok kasus dibandingkan dengan yang pembanding.

Keyword :

Lipoprotein(a), acute coronary syndrome, stable angina pectoris,


References :

  1. Bassand JP, Hamm CW, Ardissino D, Boersma E, Budaj A, Fernandez-Aviles, F, et al, (2007). Guidelines for the diagnosis and treatment of non-STsegment elevation acute coronary syndromes. vol.28 no.13 hal 1-53 : Eur Heart J
  2. Rifai N, Warnick GR, (2006). Lipids, lipoprotein, Apolipoprotein and Other Cardiovascular Risk Factors. In: Burtis C, Ashwood E, Bruns D, eds. Tietz textbook of clinical chemistry and molecular diagnostics 4th Ed.. 903-81 : Elsevier Saunders


   


Archive Article

Cover Media Content

Volume : 21 / No. : 2 / Pub. : 2015-03
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  12. Blood glucose test between hexokinase with glucose oxidase and glucose dehydrogenase methods in diabetes mellitus
  13. β-thalassemia trait using capillary electrophoresis
  14. Lipoprotein(a) in acute coronary syndrome
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