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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 21 / No. 1 / Published : 2014-01

TOC : 12, and page :57 - 60

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Original Article :

Liver function parameters based on degree of liver fibrosis in chronic liver disease

Author :

  1. Rahmafitria*1
  2. Mutmainnah*2
  3. Ibrahim Abdul Samad*3
  1. Bagian llmu Patologi Klinik FK UNHAS-BLU RSUP Dr.Wahidin Sudirohusodo Makassar.
  2. Bagian llmu Patologi Klinik FK UNHAS-BLU RSUP Dr.Wahidin Sudirohusodo Makassar.
  3. Bagian llmu Patologi Klinik FK UNHAS-BLU RSUP Dr.Wahidin Sudirohusodo Makassar.

Abstract :

Evaluating the degree of liver fibrosis degree is invasive as well as uncomfortable, therefore, non invasive examinations such as liver function tests and elastography (Fibro Scan) as a predictor‘s device of liver fibrosis degree are necessary. The aim of this study was to know the differences of liver function parameters based on the fibrosis degree in patients with chronic liver disease. This study was a cross sectional design using data from chronic liver disease patients treated at the Dr. Wahidin Sudirohusodo Hospital. The elasticity of the liver was measured using a fibro scan device during June 2010–July 2011. The analysis was carried out by ANOVA test on various parameters of liver function particularly on the fibrosis degree in chronic liver disease. In this study PT, albumin, total bilirubin and platelet count showed a significant difference of 0.019, 0.009, 0.017 and 0.000 respectively. The mean values of PT and total bilirubin were significantly higher in the high degree of fibrosis compared to those with medium and low degree of fibrosis in the chronic liver disease patients. Based on this study, the mean albumin levels and platelet count were significantly lower in the high degree of fibrosis compared with the medium and low degree of fibrosis, however, no significant differences in AST, ALT, APTT and GGT were found. Pemeriksaan untuk menilai derajat fibrosis hati yang bersifat invasif kurang diminati, oleh karena itu diperlukan cara yang bersifat noninvasif seperti yang terkait fungsi hati dan elastografi ( fibro scan) sebagai peramal derajat fibrosis hati. Penelitian ini bertujuan untuk mengetahui perbedaan tolok ukur fungsi hati berdasarkan derajat fibrosis bagi pasien penyakit hati kronis. Penelitian ini dilakukan secara potong silang menggunakan data pasien pengidap penyakit hati kronis yang menjalani perawatan di RS Dr. Wahidin Sudirohusodo dan telah diukur elastisitas hati menggunakan alat fibro scan Juni 2010-juli 2011. Analisis uji beda dengan Anova di berbagai tolok ukur fungsi hati berdasarkan derajat fibrosis bagi penyakit hati kronis menunjukkan keberadaan perbedaan nilai yang bermakna di PT, kadar albumin, jumlah keseluruhan bilirubin dan trombosit masing-masing dengan nilai kemaknaan: 0,019, 0,009, 0,017 dan 0,000. Rerata nilai PT dan jumlah keseluruhan bilirubin lebih tinggi secara bermakna pada derajat fibrosis yang tinggi dibandingkan dengan yang sedang dan rendah di pasien penyakit hati kronis. Rerata kadar albumin dan jumlah trombosit darah lebih rendah secara bermakna pada derajat fibrosis yang tinggi dibandingkan dengan yang sedang dan rendah dan tidak didapatkan perbedaan yang bermakna di: SGOT, SGPT, APTT dan GGT pada penelitian ini.

Keyword :

Degree of liver fibrosis, fibro scan, parameters of liver function, chronic liver disease,


References :

  1. Sosromihardjo R, Giantini A dan Yusra, (2007). Pemeriksaan Laboratorium pada Penyakit Hati dalam Buku Ajar Ilmu Penyakit Hati. hal 17-24 : Fakultas Kedokteran Universitas Indonesia
  2. McMachon BJ., (2009). The Natural History of Cronic Hepatitis B viral infection. vol 49 No 5 hal 545-555 : Hepatology


   


Archive Article

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Volume : 21 / No. : 1 / Pub. : 2014-01
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