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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 21 / No. 1 / Published : 2014-01

TOC : 6, and page :24 - 27

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Original Article :

Mean platelet volume in diabetes mellitus

Author :

  1. Maria Enrica*1
  2. Nina Tristina*2
  3. Anna Tjandrawati*3
  1. Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung
  2. Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung
  3. Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung

Abstract :

  New layer...Diabetes Mellitus (DM) is a state of chronically hyperglycemia, which is caused by impaired insulin secretion and function. Thealteration in coagulation system in DM patients served as the basic etiology of macro and micro vascular complication. Platelets are oneof the factors that have a role in the coagulation system and undergo pathological changes in DM patients. Mean Platelet Volume (MPV)is an indicator of platelet function and activation. Larger platelets have more dense and more reactive pro coagulant granules. The aimof this study was to know whether there were differences in MPV between DM patients compared to medical check-up participants atthe Dr. Hasan Sadikin Hospital, Bandung.. The research used analytical descriptive, retrospective data. The inclusion criteria of thisresearch was DM patients and medical check up participants whose serum fasting glucose and two (2) hours post prandial serum glucosewere within the normal range. The data were taken from medical records of DM patients and medical check up participants. The datawere further analyzed with SPSS ver. 15 program using unpaired T-test. In this study, no significant difference between DM patientsand medical check up participants (p>0.05) was found. It can be concluded that Mean Platelet Volume if used as single, can not predictvascular complication in DM patients. New layerDiabetes Melitus (DM) merupakan kondisi hiperglikemia kronis tertentu yang disebabkan oleh gangguan sekresi dan fungsihormon insulin. Komplikasi DM yang utama adalah makro dan mikrovaskular yang disebabkan perubahan sistem pembekuandarah. Trombosit merupakan salah satu faktor yang berperan di sistem pembekuan darah dan di pasien DM terdapat perubahanhal tersebut. Mean Platelet Volume (MPV) merupakan penunjuk fungsi dan aktivasi trombosit. Trombosit yang berukuran besardihubungkan dengan granula prokoagulan yang semakin padat dan lebih reaktif. Untuk mengetahui apakah terdapat perbedaanMPV yang bermakna antara populasi DM dengan peserta Medical Check-Up (MCU) di RSUP Dr. Hasan Sadikin Bandung. Metodeyang digunakan pada penelitian ini adalah deskriptif analitik, menggunakan data retrospektif. Patokan kesertaan pada penelitianini adalah pasien yang sudah didiagnosis mengidap DM, serta peserta MCU dengan kadar glukosa darah puasa dan yang dua (2) jampostprandial (pp) yang normal. Data diambil dari rekam terkait kesehatan pasien DM dan peserta MCU. Penelitian ini diolah denganprogram SPSS ver. 15 menggunakan uji –t tidak berpasangan. Berdasarkan kajian ini, tidak terdapat perbedaan MPV bermaknaantara populasi DM dan peserta MCU (p>0,05). Didasari telitian ini dapat disimpulkan bahwa tolok ukur MPV secara tunggal tidakdapat digunakan sebagai petanda komplikasi vaskular di populasi DM....

Keyword :

Platelet activation, diabetes mellitus, micro and macrovascular complication, mean platelet volume,


References :

  1. Kakouros N, Rade J, Kourliouros A, Resar J, (2011). Platelet Function in Patients with Diabetes Mellitus: From a Theoretical to a Practical Perspective. Hal : 2011 : International Journal of Endocrinology
  2. Zuberi B, Akhtar N, Afsar S, (2008). Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose, and non-diabetic subjects. Vol. 49, No.2 Hal : 114-6 : Singapore Med J


   


Archive Article

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Volume : 21 / No. : 1 / Pub. : 2014-01
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  2. Correlation plasma fibrinogen with intima-media thickness of carotid artery in diabetes mellitus
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  4. Potassium in multidrug resistance tuberculosis with kanamycin
  5. Safe blood and voluntary non-remunerated blood donors
  6. Mean platelet volume in diabetes mellitus
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