UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 19 / No. 1 / Published : 2012-01

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Original Article :

Mean platelet volume in stroke

Author :

  1. Besse Rosmiati*1
  2. Sulina Y Wibawa*2
  3. Darmawaty ER *3
  1. Bag PK FK-UNHAS Makassar
  2. Bag PK FK-UNHAS Makassar
  3. Bag PK FK-UNHAS Makassar

Abstract :

       Ischemic stroke is the cause of most cases which occur due to obstruction, this pathogenesis  can be caused by the formation of thrombus in the cerebrum blood vessels. Platelet aggregation plays a role in the pathogenesis of thromboembolic cerebrovascular disease. Platelets size, measured as Mean Platelet Volume (MPV) is a marker of platelet function and is associated with the indicator of platelet activity. Several studies have found that there was an increased of MPV in acute ischemic stroke while the correlation with the severity and outcome of stroke was still controversial. The aim of study is to determine the MPV and their association with outcomes in acute ischemic stroke patients. A cohort study during May up to July 2010 was carried out, the researchers measured MPV and analyze their correlation with its outcome using modified Rankin scale score 10 days after the onset in 33 acute ischemic stroke patients. The mean of MPV for the first three days of the onset was 8.9 fl, on the 5th day was increased up to 9.4 but at the 10th day of onset the MPV remains the same value as the 5th day. The MPV of first three days and 5th day have a positive correlation, but insignificant with their outcome, with p values 0.158 and 0.06, respectively. From this study can be concluded that the increased of MPV on the fifth day onset did not have any significant correlation with the outcome of acute ischemic stroke illness.     Strok akibat iskemik merupakan penyebab sebagian besar kasus yang terjadi karena penyumbatan yang dapat disebabkan oleh darah beku (trombus) yang terbentuk dalam pembuluh darah otak besar (serebrum). Agregasi trombosit berperan pada perjalanan penyakit tromboemboli serebrovaskular. Ukuran trombosit diukur Mean Platelet Volume (MPV) yang merupakan petanda fungsi trombosit dan berhubungan dengan penunjuk aktivitas trombosit. Di beberapa telitian ditemukan peningkatan MPV strok akibat iskemik akut, sedangkan pendapat hubungan dengan berat dan keluaran strok masih kontroversial. Tujuan penelitian ini adalah untuk mengetahui dan menentukan nilai MPV strok akibat iskemik akut dan menentukan hubungan MPV dengan keluaran di pasien yang mengidap strok akibat iskemik akut. Penelitian dilakukan secara sama ciri selama masa waktu Mei - Juli 2010, MPV diukur dan dianalisis hubungannya dengan keluaran menggunakan angka modified Rankin Scale 10 hari setelah awal penyakit di 33 pasien pengidap strok iskemik akut. Nilai rerata MPV pada tiga hari pertama awal penyakit adalah 8,9 fl, dan pada hari kelima  meningkat menjadi 9,4, tetapi  pada hari kesepuluh MPV tetap sama dengan awal penyakit hari kelima. MPV pada tiga hari pertama dan hari kelima dengan keluaran bernasab positif, tetapi tidak bermakna dengan nilai p masing-masing 0,158 dan 0,06. Didasari hasil telitian ini dapat disimpulkan bahwa MPV meningkat pada hari kelima awal penyakit, tetapi tidak berhubungan bermakna dengan keluaran strok akibat iskemik akut.

Keyword :

Stroke, mean platelet volume, , outcome,


References :

Ranakusuma T,(2004) Pedoman Penatalaksanaan Stroke Bagi Dokter Umum. Dalam: Updates In Neuroemergencies Jakarta : Balai Penerbit FKUI

Sri Hartanto O,(2009) Pencegahan Primer Strok Iskemik dengan mengendalikan Faktor Risiko Surakarta : http://www.pustaka.uns.ac.id

Kesehatan,(2009) Stroke Penyebab Kematian Tertinggi Jakarta : http://www.dhamacakka.org/forum/archive/index/.php2t-1650.html

Hartwig M S,(2006) Penyakit Serebrovaskular. Dalam: Patofisiologi Konsep Klinis Proses-Proses Penyakit Jakarta : Penerbit Buku Kedokteran EGC

Tohgi H, Suzuki H, et al,(1991) Platelet Volume, Aggregation, and Adenosine Triphosphate Release in Cerebral Thrombosis USA : In: Stroke





Archive Article

Cover Media Content

Volume : 19 / No. : 1 / Pub. : 2012-01
  1. Pulmonary Cryptosporidiosis In Hiv And Aids
  2. Aerob Bacteria And Antimicrobial Susceptibility
  3. Plasma Volume And Factor Viii In Cryoprecipitated
  4. Comparation Measurement Triglycerides, Glycerol Blanking And Non Glycerol Blanking In Liver Cirrhosis
  5. The Residue Of Leukocyte In Thrombocyte Concentrate
  6. Antimicrobial Sensitivity Of Blood Culture In Neonatal Sepsis
  7. Neutrophils Lymphocyte Ratio In Acute Appendicitis
  8. Curcuma Zedoaria And Morinda Citrifolia As Hepatoprotector Against Carbontetrachloride
  9. Mean Platelet Volume In Stroke
  10. Dengue Serotypes Distribution In Surabaya In The Year 2012
  11. M.tuberculosis In Innate Immunity Associated With The Receptors
  12. Ovarian Dysgerminomas Cancer
  13. Information System In Laboratory Services

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