UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 16 / No. 1 / Published : 2009-11

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Original Article :

Measurement and clinical application of thrombin activatable fibrinolysis inhibitor

Author :

  1. Mansyur Arif*1
  1. Subdivisi Hematologi-Onkologi Bagian Ilmu Patologi Klinik FK UNHAS Makassar Alamat rumah: Jl. Tala Salapang Villa Taman Madani A1 Makassar Telp. 0816277020

Abstract :

Cross regulation of coagulation and fibrinolysis plays an important role in preserving a balanced hemostatic process. These process are exquisitely regulated and protect the organism from excessive blood loss or excessive fibrin deposition. Identification of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) as an inhibitor of fibrinolysis and one of the main intermediates between coagulation and fibrinolysis, greatly improved our understanding of cross regulation of coagulation and fibrinolysis. As TAFI is an enzyme that is activated by thrombin generated by the coagulation system, its activation is sensitive to the dynamics of the coagulation system. This review will discuss the role of TAFI and characterize it with respect to its activation, regulation, and clinical application.

Keyword :

TAFI, coagulation, fibrinolysis,


References :

Nesheim M,(2003) Thrombin and Fibrinolysis Washington DC : CHEST





Archive Article

Cover Media Content

Volume : 16 / No. : 1 / Pub. : 2009-11
  1. Homolog Legionella Pneumophila Distribution And Nosocomial Pneumopniae
  2. Diagnostic Value Of Malaria Antigen Cassette On Malaria Disease
  3. Cd4 Analysis In Treatment Of Hiv-tb Co-infected Patients
  4. Analysis Of Uric Acid Level In Patients Of Carcinoma Mammae
  5. Anti Hcv And The Patient’s Prevalence Of Virus Hepatitis C Infection
  6. The Evaluation Of Transaminase Activities, And Bilirubin Level In Patients With Hepatitis B Virus And C Virus
  7. Correlation Degree Of Non-alcoholic Fatty Liver With Aminotransferase Serum Activity
  8. Accuracy Of Bactident Aminopeptidase Test In Identification Gram Negative Bactery)
  9. Study Of Cd38 Expression On Lymphocyte 8+, Cd4+ Profile, And Clinical State Immunological And Clinical State Profile Of Aids/hiv Patients With Antiretroviral Therapy)
  10. Eosinofil After Mucosal Nasal Brushing And Routine Hematology In Allergy Rhinitis
  11. Normoblast Counting Between Acute Myeloblast Leukemia And Acute Lymphoblastic Leukemia In Peripheral Blood Smear Of Patients
  12. Measurement And Clinical Application Of Thrombin Activatable Fibrinolysis Inhibitor
  13. Abnormal Trombosit In Post-partum
  14. Laboratory Costing Per Test Based On Jaros Ml Method

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