UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 16 / No. 1 / Published : 2009-11

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Original Article :

Normoblast counting between acute myeloblast leukemia and acute lymphoblastic leukemia in peripheral blood smear of patients

Author :

  1. Hidayat*1
  2. Nina Susana Dewi*2
  3. Nadjwa Zamalek Dalimoenthe*3
  1. Sub Bagian Hematologi Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Hasan Sadikin Bandung
  2. Subbagian Hematologi Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin Bandung
  3. Subbagian Hematologi Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin Bandung

Abstract :

Normoblast is an immature form of erythrocyte in erythropoietin system. Normally, normoblast can be found in peripheral blood healthy neonates. The existence of normoblast in peripheral blood might be the sign of pathologic conditions such as hemolytic anemia, acute blood loss, and ischemia and bone marrows abnormalities like malignancy or leukemia. In acute leukemia (Acute Myeloblastic Leukemia and Acute Lymphoblastic Leukemia), normoblast existence in peripheral blood may due to erythropoietin system suppression. The aim of this study is to compare normoblast count between AML and ALL, and also to find out the correlation between leukocyte and normoblast count in AML and ALL. The subject of this study were patient diagnosed as AML (30) and ALL (30) in Hematology Division of Clinical Pathology Department at Dr.Hasan Sadikin Hospital Bandung in July 2006–August 2008. In this study we examined 30 peripheral blood smears from AML and 30 peripheral blood smears from ALL. Leukocyte count result was derived from CBC performed with Sysmex KX-21. The mean value of normoblast count from AML blood smear patients is 1930.60 (3.60/100 WBC) while ALL blood smear patients is 309.60 (0.43/100 WBC). Statistically this difference is significant (p < 0.001). There are strong correlation between leukocyte count and normoblast count within both group (r = 0.851, r = 0.948; p < 0.001).

Keyword :

Normoblast, AML, ALL, leukocyte,


References :

Kurniada J,(2006) Leukemia Mieloblastik Akut Jakarta : Balai penerbit FK UI





Archive Article

Cover Media Content

Volume : 16 / No. : 1 / Pub. : 2009-11
  1. Homolog Legionella Pneumophila Distribution And Nosocomial Pneumopniae
  2. Diagnostic Value Of Malaria Antigen Cassette On Malaria Disease
  3. Cd4 Analysis In Treatment Of Hiv-tb Co-infected Patients
  4. Analysis Of Uric Acid Level In Patients Of Carcinoma Mammae
  5. Anti Hcv And The Patient’s Prevalence Of Virus Hepatitis C Infection
  6. The Evaluation Of Transaminase Activities, And Bilirubin Level In Patients With Hepatitis B Virus And C Virus
  7. Correlation Degree Of Non-alcoholic Fatty Liver With Aminotransferase Serum Activity
  8. Accuracy Of Bactident Aminopeptidase Test In Identification Gram Negative Bactery)
  9. Study Of Cd38 Expression On Lymphocyte 8+, Cd4+ Profile, And Clinical State Immunological And Clinical State Profile Of Aids/hiv Patients With Antiretroviral Therapy)
  10. Eosinofil After Mucosal Nasal Brushing And Routine Hematology In Allergy Rhinitis
  11. Normoblast Counting Between Acute Myeloblast Leukemia And Acute Lymphoblastic Leukemia In Peripheral Blood Smear Of Patients
  12. Measurement And Clinical Application Of Thrombin Activatable Fibrinolysis Inhibitor
  13. Abnormal Trombosit In Post-partum
  14. Laboratory Costing Per Test Based On Jaros Ml Method

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