UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 17 / No. 2 / Published : 2017-11

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Original Article :

Pathogenesis and laboratory examination of primary myelofibrosis

Author :

  1. johanis*1
  2. Arifoel Hajat*2
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Primary myelofibrosis (PMF) is a neoplastic hematologic disease, characterized by clonal hemapoietic stem cell and collagen accumulation in bone marrow. PMF is not related with underlying myeloproliferative disorders or other diseases. The features of PMF show marrow fibrosis, megakaryocytes and granulocytes proliferation, and extramedullary hemapoiesis. PMF is classified as BCR-ABL-negative myeloproliferative disorders. Diagnosis of PMF is based on clinical symptoms of splenomegaly and myelopthisis; bone marrow biopsy shows granulocytes/megakaryocytes hyperplasia, megakaryocytes dysmorphic and fibrosis; cytogenic testing for mutation of JAK2V617F+, MPLW5I5L/K+ and BCR-ABL. The diagnostic criterion according to the 2008 WHO classification considers major and minor crieria. The primary purpose for treatment is to improve the quality of life by paliative tratment. The five year survival of PMF patients is low.

Keyword :

Phatogenesis, primary myelofibrosis, laboratory examination,


References :

Ciesla B,(2007) Hematology in Practice Washington DC : FA. Davis Company





Archive Article

Cover Media Content

Volume : 17 / No. : 2 / Pub. : 2010-11
  1. The Diagnostic Value Of Heart-type Fatty Acid Binding Protein (h-fabp) Rapid Test Related To Cardiac Troponin I In Non St Elevation Myocardial Infarction (nstemi)
  2. The Creatinine Level And Potassium Serum In Patients With And Without Type Ii Diabetic
  3. Procalcitonin For The Differentiation Of Bacterial And Non Bacterial Infection
  4. Diagnosis Of Dengue Virus Infection With Iga Anti Dengue Rapid Tests
  5. The Platelet Aggregation Test As A Predictor Of Clinical Outcome In Acute Infarction Stroke
  6. Association Between Atypical Depolarization On The Cell-dyn 3200 And The Presence Of Plasmodium Spp In Blood In The Dr. Soetomo Hospital Surabaya
  7. The Correlation Between Thrombocyte And Cd4 Count In Hiv/aids Patients
  8. The Chemotherapy Effect In The Activity Of Transaminase Enzymes In Breast Cancer Patients
  9. Pathogenesis And Laboratory Examination Of Primary Myelofibrosis
  10. Star ()-flagged Leukocytosis As Indicator Of Interfering Factor In Automatic Hematology Analyzer
  11. (oral Administration Of Mycobacterium Tuberculosis 38-kilodalton Adhesin Protein Increases Macrophages And Lymphocytes In Intestinal Balb/c Mice)
  12. Diazo Test As A Screening Test Of Typhoid Fever A Practical Approach

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