UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 15 / No. 3 / Published : 2009-07

Related with : Scholar   Yahoo!   Bing

Original Article :

Patients’ serum protein electrophoresis with normal serum total protein level

Author :

  1. Tiene Rostini*1
  2. Coriejati Rita*2
  1. Sub Bagian Kimia Klinik, Bagian Patologi Klinik, Rumah Sakit Dr Hasan Sadikin/ Fakultas Kedokteran Universitas Padjadjaran Bandung
  2. Sub Bagian Kimia Klinik, Bagian Patologi Klinik, Rumah Sakit Dr Hasan Sadikin/ Fakultas Kedokteran Universitas Padjadjaran Bandung

Abstract :

Serum protein electrophoresis pattern can assist in diagnosis of liver disease, hematological disorders, renal disorders and gastrointestinal disease. Measurement of total protein level in the serum cannot detect any disorders in patient with normal limit of serum total protein level. The aim of this study; was to evaluate the serum protein electrophoresis pattern in patient with normal limits of serum protein level. This research was carried out by descriptive retrospective study using the electrophoresis data from patients’ medical record at the Clinical Pathology Department, Dr. Hasan Sadikin General Hospital Bandung. The data of serum electrophoresis (by Sebia gel electrophoresis) were grouped based on disease or disorders, and confirmed with the diagnosis derived from patient’s medical record. Inclusion criteria of samples if ; the electrophoresis data were available, serum total protein level within normal limits (6.4–8.3 mg/dL), and the data of electrophoresis taken from medical record were taken from August 2006 until August 2008. The result found so far was, there were 240 data of electrophoresis from patients with serum protein level within normal limits (6.4–8.3 mg/dL). the interpretation of electrophoresis consist of: 1) inflammation (149 patients; 62.2% ; sensitivity 83.7%, specificity 86,5%) 2) Cirrhosis (46 patients ; 19.2% ; sensitivity 87.5% ; specificity 88.4%) 3) Nephritic syndrome (15 patients ; 6.2%; sensitivity 53%; specificity 96.9% 4) Monoclonal gammophaty (15 patients(6.2% ; sensitivity 80% ; specificity 98.7%) 5) Normal pattern in 15 patient (6.2%). This study found abnormal serum protein electrophoresis pattern in the condition of inflammation, Cirrhosis, Nephritic Syndrome, and Monoclonal gammophaty. It can be concluded that many disorders could be detected in patient with serum protein level within normal limits such as: inflammation, cirrhosis, nephritis syndrome and monoclonal gammophaty by abnormal electrophoresis pattern

Keyword :

serum protein electrophoresis, normal limit of serum total protein,


References :

Gaedeke MK,(1996) Laboratory and diagnostic test handbook California : Addison Wesley Publising Company Inc





Archive Article

Cover Media Content

Volume : 15 / No. : 3 / Pub. : 2009-07
  1. Cd4 Cell Counts With Igm Herpes Simplex-type 2 In Hiv Patients
  2. The Transferrin Saturation Profile Among Anaemic Blood Donors
  3. Iron Deficiency Anemia Of Babies
  4. Patients’ Serum Protein Electrophoresis With Normal Serum Total Protein Level
  5. Inflammatory Marker Hs Crp With Hipertension
  6. Comparison Of Kalium Serum Level With Or Without Insulin Therapy At Type 2 Diabetic Mellitus Patiens
  7. Microalbuminuria Of Type 2 Dm Patients
  8. Analysis Of The Immunochromatography And Enzyme-linked Immunosorbent Assay Tests To Diagnose Helicobacter Pylori In Dyspepsia
  9. Soluble Transferrin Receptor Level In Human Immunodeficiency Virus/acquired Immunodeficiency Syndrome Patients With Anemia
  10. Comparison Of Specthrophotometer Method With Hemocue Method For Haemoglobin Measurement In Leucocytosis Sample
  11. Toll-like Receptor (tlr) And Natural Immunity
  12. A Retinoid Acid Receptor In Acute Promyelocytic Leukemia Auer Rods
  13. Errors During Clinical Laboratoric Procedures

Information CPML