UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 21 / No. 2 / Published : 2015-03

Order : 5, and page :130 - 134

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Original Article :

Platelet aggregation and mean volume with metabolic syndrome in obesity

Author :

  1. Nindia Sugih Arto*1
  2. Adi Koesoema Aman*2
  3. Dharma Lindarto*3
  1. Departemen Patologi Klinik, Fakultas Kedokteran Universitas Sumatera Utara/RSUP H. Adam Malik Medan
  2. Departemen Patologi Klinik, Fakultas Kedokteran Universitas Sumatera Utara/RSUP H. Adam Malik Medan
  3. Departemen Ilmu Penyakit Dalam Divisi Endokrinologi, Fakultas Kedokteran Universitas Sumatera Utara/RSUP H. Adam Malik Medan

Abstract :

The hyperactivity of platelet had been seen in patients with metabolic syndrome which can be caused by several factors, such as: insulin resistance, obesity, dyslipidemia and hypertension. The hyperactivity of platelet leads to its aggregation that can be increased the risk of cardiovascular disease. This study is aimed to know the platelet aggregation and mean platelet volume in patients with metabolic syndrome and obesity by determination 30 patients were choosen for this cross sectional study, those whom attended to the laboratory and policlinic at H. Adam Malik Medan Hospital, between May 2013 until August 2013. The diagnosis used of metabolic syndrome criteria established by the International Diabetic Federation 2005. From the 30 patients with 15 metabolic syndrome and 15 obesity, four patients were excluded because of their tryglyceride were more than 200 mg/dL. There is no significant differences between the platelet aggregation with the agonist adenosin difosfat (ADP) in patient with metabolic syndrome and obesity. And there is no significant differences of the mean platelet volume values between the metabolic syndrome (9.6±0.93) and the obesity group (9.73±0.74), with p value 0.846. Based on this study there is no significant differences between the platelet aggregation and the Mean Platelet Volume values (MPV) in the metabolic syndrome and the obese group Kejadian hiperaktivitas trombosit terlihat di pasien dengan sindrom metabolik yang dapat diakibatkan oleh beberapa faktor seperti: resistensi insulin, kegemukan, dislipidemia dan hipertensi. Hiperaktivitas trombosit menyebabkan agregasi trombosit terjadi yang dapat meningkatkan kebahayaan penyakit kardiovaskular terjadi. Tujuan penelitian ini untuk mengetahui perbedaan nilai agregasi trombosit dan MPV di pasien dengan sindrom metabolik dan kegemukan. Penelitian dilakukan dengan metode potong lintang 30 orang yang datang ke Departemen Patologi Klinik dan Departemen Penyakit Dalam bagian Endokrin RSUP H. Adam Malik Medan masa waktu Mei 2013 sampai Agustus 2013. Diagnosis sindrom metabolik ditetapkan berdasarkan patokan IDF 2005. Dari 30 subjek didapati 11 orang terkait sindrom metabolik dan 15 dengan kegemukan. Empat (4) orang tidak disertakan karena memiliki kadar trigliserida yang tinggi (>200 mg/dL). Nilai agregasi trombosit yang didapat dengan agonis ADP tidak dijumpai secara bermakna antara kaitan sindrom metabolik dan kegemukan di nilai MPV tidak ada perbedaan yang bermakna antara pasien terkait sindrom metabolik (9,6±0,89) dan kegemukan (9,73±0,74) dengan nilai p=0,672. Didasari telitian ini tidak dijumpai perbedaan yang bermakna antara nilai agregasi trombosit dan MPV di kelompok terkait sindrom metabolik dibandingkan dengan yang kegemukan. Kata kunci: Agregasi trombosit, mean

Keyword :

Platelet aggregation, mean platelet volume, metabolic syndrome, obesity,


References :

Alberti KGMM, Zimmet PZ,(1998) For the WHO consultation, definition, diagnosis and classification of diabetes mellitus and its complications: Part 1. Diagnosis and classification of diabetes melitus. Provision report of a WHO consulation vol. 15 Hal: 539–53. : Diabet Med

Grundy SM, Cleeman JI, Daniels SR. et al,(2005) Diagnosis and management of the metabolic syndrome an American Heart Association/National Heart, Lung and Blood Institute scientific statement. Vol.112 Hal: 2735–2752. : Circulation





Archive Article

Cover Media Content

Volume : 21 / No. : 2 / Pub. : 2015-03
  1. Pneumatic Tube On Routine Blood Test And Lactate Dehydrogenase
  2. Detection In Tetrazolium Microplate Assay Culture Methods From Pulmonary Tuberculosis Suspected Sputum
  3. High Molecular Weight Adiponectin And Vasculer Thickness In Diabetes Type 2 Related To Fixed Dose Combination Of Glimepiride And Metformin
  4. Neutrofil/lymphocyte Ratio In Carcinoma Mammae
  5. Platelet Aggregation And Mean Volume With Metabolic Syndrome In Obesity
  6. Diagnosis Of Pulmonary Tuberculosis Based On Frequency Of Sputum Examination
  7. Genetic Variation Of Hepatitis B Virus Polymerase Gene From Chronic Hepatitis B Infected Patient With Telbivudine Therapy
  8. The 38 Kda Adhesin Protein Of Mycobacterium Tuberculosis And Macrophage Of The Lung
  9. Bacterial Pattern And Patient’s Age On Procalcitonin In Community And Hospital Acquired Pneumonia
  10. Aspergillus Glaucus Group And Penicillium Sp In Neurosurgery Operating Theater
  11. Diagnostic Value Of Iga Antivca Epstein-barr Antibody In Nasophryngeal Carcinoma
  12. Blood Glucose Test Between Hexokinase With Glucose Oxidase And Glucose Dehydrogenase Methods In Diabetes Mellitus
  13. β-thalassemia Trait Using Capillary Electrophoresis
  14. Lipoprotein(a) In Acute Coronary Syndrome
  15. D-dimer Plasma Levels In Ishemic Stroke
  16. Adrenomedullin’s In Breast Cancer With Metastatic State
  17. Storage Temperature For 24 Hours Of Uric Acid In Urine
  18. Ebola Virus Disease
  19. Congenital Malaria

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