UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 20 / No. 1 / Published : 2013-01

Order : 10, and page :43 - 46

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Original Article :

Platelet count in pre eclampsia patients

Author :

  1. M. Arif Muchlis*1
  2. Suci Aprianti*2
  3. Hj. Darmawati ER*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

In pregnant women who previously did not have hypertension pre eclampsia is a pregnancy complication, characterized by the increased of blood pressure, proteinuria and/or oedema. One of theory about aetiology of pre eclampsia suggests that this is caused by endothelial damage that can lead to adhesion and platelet aggregation. The aim of this study was to know the platelet count and indices by analyzing, such as mean platelet volume (MPV), its distribution width (PDW) and the large cell ratio (P-LCR) for diagnostic confirmation in pre eclampsia patients. This research was a retrospective study using secondary data of routine blood test from medical records of pre eclampsia patients who were treated at Dr. Wahidin Sudirohusodo Hospital during the period of January to December 2011 and the normal pregnant women data that were taken as control. The data obtained were platelet count, MPV, PDW, P-LCR and analyzed using independent T test. The results showed that the mean platelet count in pre eclampsia patients was lower than the control but had no statistically significant difference (p = 0.325) whereas the mean of MPV, PDW and P-LCR in pre eclampsia patients increased compared to the control group and was statistically significant with p value of MPV (p=0.003), PDW (p=0.002) and P-LCR (p =0. 010). In conclusion, platelet indices can be used as diagnostic confirmation markers in pre eclampsia patients.       Pre eklampsia merupakan komplikasi kehamilan yang ditandai dengan peningkatan tekanan darah disertai proteinuria dan atau edema di perempuan hamil yang sebelumnya tidak mengalami tekanan darah tinggi. Salah satu teori dinyatakan, bahwa pre eklampsia terjadi oleh karena ada kerusakan endotel yang dapat menyebabkan adhesi dan agregasi platelet terjadi. Tujuan penelitian ini adalah untuk mengetahui jumlah platelet dan indeksnya, yaitu mean platelet volume (MPV), platelet distribution width (PDW) dan platelet large cell ratio (PLCR) secara menganalisis, untuk memastikan diagnostik di penderita pre eklampsia. Penelitian ini merupakan kajian tinjauan ke belakang dengan mengambil data sekunder dari rekam medik hasil periksaan darah rutin bagi penderita pre eklampsia yang dirawat di RS Dr.Wahidin Sudirohusodo selama masa waktu bulan Januari sampai Desember 2011. Sebagai pembanding diambil data ibu hamil yang normal. Data yang didapat berupa hitungan jumlah trombosit, MPV, PDW, P-LCR yang dianalisis menggunakan uji T tidak berpasangan. Hasil telitian didapatkan rerata jumlah platelet di penderita pre eklampsia lebih rendah dibandingkan dengan kelompok pembanding, tetapi secara statistik tidak mempunyai perbedaan yang bermakna (p=0,325). Namun, nilai rerata MPV, PDW dan P-LCR di penderita pre eklampsia meningkat dibandingkan dengan kelompok pembanding, dan bermakna secara statistik dengan nilai p masing-masing MPV(p=0,003), PDW(p=0,002) dan P-LCR(p=0,010). Di dasari hal tersebut dapat disimpulkan bahwa indeks platelet dapat dijadikan sebagai petanda untuk memastikan diagnostik terkait penderita pre eklampsia.

Keyword :

Pre eclampsia, platelet count,


References :

Kaito K et all,(2005) Platelet size deviation width, platelet large cell ratio and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia London : British Journal of Haematology





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  10. Platelet Count In Pre Eclampsia Patients
  11. Fusion Of Gen Breakpoint Cluster Region Abelson Kinase (bcr-abl) And Routine Haematological Test
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