UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 17 / No. 2 / Published : 2010-11

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Original Article :

Procalcitonin for the differentiation of bacterial and non bacterial infection

Author :

  1. Bastiana*1
  2. Aryati*2
  3. Dominicus Husada*3
  4. MY. Probohoesodo*4
  1. Departemen/Instalasi Patologi Klinik FK. UNAIR/RSUD. Dr. Soetomo, Surabaya
  2. Departemen/Instalasi Patologi Klinik FK. UNAIR/RSUD. Dr. Soetomo, Surabaya
  3. Departemen/SMF Ilmu Kesehatan Anak FK.UNAIR/RSUD. Dr. Soetomo, Surabaya
  4. Departemen/Instalasi Patologi Klinik FK. UNAIR/RSUD. Dr. Soetomo, Surabaya

Abstract :

Early diagnosis of an infection and prompt administration of an antibiotic can dramatically reduce morbidity and mortality. Procalcitonin (PCT), a precursor of calcitonin, has been proposed as a marker of bacterial infection. The aim of this study is to assess the efficiency of procalcitonin in children for the diagnosis of bacterial vs. non bacterial infection. This was a prospective, cross-sectional study. The subjects were enrolled consecutively, consisting of feverish children (temperature ³38.5° C) admitted to the Pediatric Emergency Department with ages up to 12 years old. The subjects were divided into two groups according to their final diagnosis, bacterial and non bacterial infection. Serum PCT concentration was measured by enzyme linked fluorescent assay (ELFA) method. Sensitivity, specificity, positive predictive and negative predictive values, and receiver operating curve (ROC) of PCT were calculated. Out of 54 patients,24 (44.4%) had a final diagnosis of bacterial infection. PCT showed a wide concentration range in the bacterial infection group (median: 1.09 ng/mL, lower (L)=0.05 ng/mL, upper (U)=128.7 ng/mL) compared with non bacterial infection group (0.21 ng/mL; L=0.05 ng/mL; U=12.15 ng/mL). There was a significant difference in PCT between the 2 groups (p=0.020). ROC analysis demonstrated an area under curve (AUC) of 0.686 (95% CI, 0.534 to 0.838). Using a cut-off point of 0.5 ng/mL, the sensitivity, and specificity, positive predictive and negative predictive values of PCT were 66.7%, 76.7%, 69.6%, 74.2%, respectively. In this study, PCT may be useful for differentiation of bacterial vs. non bacterial infection in children.

Keyword :

Procalcitonin, bacterial infection, non bacterial infection,


References :

Soedarsono,(2006) Pneumonia Surabaya : Graha Masyarakat Ilmiah Kedokteran Unair





Archive Article

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Volume : 17 / No. : 2 / Pub. : 2010-11
  1. The Diagnostic Value Of Heart-type Fatty Acid Binding Protein (h-fabp) Rapid Test Related To Cardiac Troponin I In Non St Elevation Myocardial Infarction (nstemi)
  2. The Creatinine Level And Potassium Serum In Patients With And Without Type Ii Diabetic
  3. Procalcitonin For The Differentiation Of Bacterial And Non Bacterial Infection
  4. Diagnosis Of Dengue Virus Infection With Iga Anti Dengue Rapid Tests
  5. The Platelet Aggregation Test As A Predictor Of Clinical Outcome In Acute Infarction Stroke
  6. Association Between Atypical Depolarization On The Cell-dyn 3200 And The Presence Of Plasmodium Spp In Blood In The Dr. Soetomo Hospital Surabaya
  7. The Correlation Between Thrombocyte And Cd4 Count In Hiv/aids Patients
  8. The Chemotherapy Effect In The Activity Of Transaminase Enzymes In Breast Cancer Patients
  9. Pathogenesis And Laboratory Examination Of Primary Myelofibrosis
  10. Star ()-flagged Leukocytosis As Indicator Of Interfering Factor In Automatic Hematology Analyzer
  11. (oral Administration Of Mycobacterium Tuberculosis 38-kilodalton Adhesin Protein Increases Macrophages And Lymphocytes In Intestinal Balb/c Mice)
  12. Diazo Test As A Screening Test Of Typhoid Fever A Practical Approach

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