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Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 20 / No. 1 / Published : 2013-01

TOC : 12, and page :51 - 58

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Original Article :

Secondary iron overload related with transferrin saturation and ferritin

Author :

  1. Isabella Valentina*1
  2. Ninik Sukartini*2
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Iron overload disorder is a condition due to an excessive rate of iron acquisition compared to the rate of body iron loss that happens constantly. The clinical manifestations vary depending on the location of the damaged organs. Consequently, the symptoms of iron overload may mimic many diseases such as cirrhosis, diabetes mellitus, arthropathy, and skin pigmentation. The laboratory results which may point to iron overload are as follows: transferrin saturation > 45%, serum ferritin level > 300 ng/ml in men and > 200 ng/ml in women. It is thus imperative that the molecular mechanism of iron metabolism and pathogenesis of iron overload are well understood in order to correct the interpretation of the laboratory results for iron overload. The standard management is blood removal by phlebotomy to maintain the level of the serum ferritin at 50 ng/mL in order to prevent irreversible hepatic cirrhosis.     Penyakit kelebihan zat besi merupakan keadaan tertentu yang terjadi akibat kecepatan pemasukan zat besi melebihi pembuangan zat besi tubuh yang terjadi secara terus menerus. Manifestasi klinisnya beragam, bergantung lokasi kerusakan organnya, sehingga gejalanya dapat menyerupai berbagai penyakit seperti sirosis hati, diabetes melitus, penyakit sendi (artropati), dan pigmentasi kulit. Tolok ukur yang menunjukkan kecurigaan adanya kelebihan zat besi adalah saturasi transferrin > 45%, kadar serum feritin > 300 ng/mL untuk laki–laki dan > 200 ng/mL bagi perempuan. Mekanisme molekul metabolisme besi dan perjalanan penyakit kelebihan zat besi penting untuk dipahami dalam menafsirkan hasil laboratorik terkait. Penatalaksanaan baku adalah flebotomi untuk mempertahankan kadar serum feritin 50 ng/mL agar sirosis hati yang ireversibel tercegah.

Keyword :

Secondary iron overload, transferrin saturation, ferritin,


References :

  1. Mckenzie SB, (2010). Anemias of disordered iron metabolism and heme synthesis. New Jersey : Pearson Education Inc


   


Archive Article

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Volume : 20 / No. : 1 / Pub. : 2013-01
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