UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 20 / No. 1 / Published : 2013-01

Order : 3, and page :12 - 15

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Original Article :

Serum albumin in liver cirrhosis

Author :

  1. Windu Nafika*1
  2. Leonita Anniwati*2
  3. Soehartini*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Serum albumin measurement can be used for assessing prognosis, determining initial therapy and treatment efficacy for liver cirrhosis patients. The discrepancy result of albumin measurement using different methods can make bias for the albumin concentration. The measurement of albumin was carried out in 20 sera of liver cirrhosis patients using bromcresol green (BCG), BCG conversion as well as bromcresol purple (BCP) methods including protein electrophoresis. The results showed that BCP method has a lower albumin concentration than the other kind (1.68 ± 0.35), BCG (1.94 ± 0.31), BCG conversion (2.09 ± 0.45) as well as protein electrophoresis (2.14 ± 0.35).  BCP method has a good correlation with protein electrophoresis as well as BCG conversion (r = 0.935 and r = 0.90 respectively). It can be concluded in this study, that albumin measurement with BCP method has a good correlation with  protein electrophoresis. It is important to know that the measurement results of BCP method is lower but more accurate in the albumin concentration, because there is no cross reaction with globulin. That means, there is no overestimation of albumin concentration in hypoalbuminemia condition of the patients.     Serum albumin dapat digunakan untuk menilai ramalan perjalanan penyakit, menentukan awal pengobatan dan keberhasilannya bagi penderita sirosis hati. Perbedaan metode memeriksa kadar albumin dapat memberikan hasil yang berbeda dan terjadi penyimpangan. Pengukuran kadar albumin dilakukan di 20 serum penderita sirosis hati dengan metode bromcresol green (BCG), BCG konversi dan bromcresol purple (BCP) serta elektroforesis protein. Metode  BCP memberikan hasil yang lebih rendah pada pengukuran albumin dibandingkan dengan jenis lainnya (1,68 ± 0,35), BCG (1,94 ± 0,31), BCG konversi (2,09 ± 0,45) dan elektroforesis protein (2,14 ± 0,35). BCP memiliki kenasaban yang baik dengan elektroforesis protein dan BCG konversi (r = 0,935 dan r= 0,90 berurutan). Pengukuran albumin dengan metode BCP memiliki kenasaban yang baik dengan jenis elektroforesis protein. Penting untuk diketahui bahwa kenasaban BCP memberikan nilai yang lebih rendah, tetapi  lebih cermat dalam pengukuran kadar albumin, sebab dengan metode BCP tidak terdapat reaksi silang dengan globulin. Dengan demikian penaksiran terlalu tinggi terhadap kadar albumin penderita hipoalbuminemia tidak terjadi.

Keyword :

Albumin, liver cirrhosis ,


References :

Tel RM, Jong J, Berends GT,(1979) Bromcresol purple, a non specific colour reagent for the determinanation of serum albumin London : J. Clin. Chem.Clin. Biochem





Archive Article

Cover Media Content

Volume : 20 / No. : 1 / Pub. : 2013-01
  1. (lipid Ratio In Myocardial Infarction)
  2. (the Synergic Effect Of Chloroquine And N-acetyl Cysteine In Decreasing Parasitemia And Erythrocyte Malondyaldehyde Level In Balb/c Mice Infected With Plasmodium Berghei)
  3. Serum Albumin In Liver Cirrhosis
  4. Urine 5 Hidroxyindolacetic (5-hiaa) Acid In Colorectal Cancer
  5. Microrganisms And Sensitivity Tests Of Diabetic Foot
  6. Protein Disulfide Isomerase Family A Member 4 (pdia4) In Metastatic Breast Cancer
  7. Apo B / Apo A-i Ratio In Acute Coronary Syndrome
  8. Pneumocystis Pneumonia (pcp) In Hiv And Aids Patients With Pulmonary Symptom
  9. Ckmb Activity And Its Ckmb Mass As Well As Cardiac Troponin-1 In Acute Coronary Syndrome
  10. Platelet Count In Pre Eclampsia Patients
  11. Fusion Of Gen Breakpoint Cluster Region Abelson Kinase (bcr-abl) And Routine Haematological Test
  12. Secondary Iron Overload Related With Transferrin Saturation And Ferritin
  13. {(talasemia-β Di Penderita Pengidap Leukemia Limfoblastik Akut (lla)}
  14. Workload Analysis In Laboratory Installation

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