UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 15 / No. 3 / Published : 2009-07

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Original Article :

Soluble transferrin receptor level in human immunodeficiency virus/acquired immunodeficiency syndrome patients with anemia

Author :

  1. Indrati AR*1
  2. Van Crevel R*2
  3. Sumantri R*3
  4. Wisaksana R*4
  1. Bagian Patologi Klinik, RS Hasan Sadikin/FK Universitas Padjadjaran
  2. Dept. Internal Medicine, Radboud University Medical Center
  3. Bagian Ilmu Penyakit Dalam, RS Hasan Sadikin/FK Universitas Padjadjaran
  4. Bagian Ilmu Penyakit Dalam, RS Hasan Sadikin/FK Universitas Padjadjaran

Abstract :

Anemia is the most common hematologic abnormality associated with HIV which affecting 60 to 80 percent of patients in the late stage of the disease. The presence of anemia is associated with increased of morbidity and mortality in patients with HIV infection. Iron deficiency, chronic inflammation and antiretroviral treatment (ACT) may cause HIV associated anemia. The differentiation of iron deficiency anemia from chronic disease anemia is a diagnostic challenge. Maybe it is helpful in soluble transferrin receptor (sTfR), the cleaving of the extra cellular domain related to transferrin receptor. Because the elevated sTfR concentration is a marker of tissue iron deficiency and increased marrow erythropoietin activity. The aim of this study was to examine the diagnostic value of soluble transferrin receptor level in anemia patients with HIV/AIDS. The Study was the part of the IMPACT (Integrated Management for Prevention, Control and Treatment of HIV/AIDS) baseline and cohort study. The study started since September 2007 in RSUP Hasan Sadikin Bandung. There were 179 HIV/AIDS patients with anemia included in this study. Complete blood count, reticulocytes, feritin, soluble transferring receptor and hsCRP were tested in these patients. It was found that the mean of sTfR in HIV patients with anemia were 1238.42U/mL (304.5-30435). sTfR had a low correlation with MCV (r -0.174), feritin (r -0.65) and absolute reticulocyte counting (r 0.172). Feritin had moderate and significant correlation with hsCRP (r:0.429; p 0.00). There was no significant difference of sTfR level between the patients without ART, with Zidovudin and d4T (p 0.81). There was no significance difference of sTfR concentration between the low and normal MCV level (p 0.341). sTfR can not differentiate the source of anemia in patients with HIV/AIDS. It can be concluded so far that chronic disease and inflammation as reflected by the elevated hsCRP level and use of zidovudine are the main cause of anemia.

Keyword :

Soluble Transferrin Receptor, Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome. Anemia,


References :

Moore RD,(2008) Hematologic Disease Canada : Churchill Livingstone





Archive Article

Cover Media Content

Volume : 15 / No. : 3 / Pub. : 2009-07
  1. Cd4 Cell Counts With Igm Herpes Simplex-type 2 In Hiv Patients
  2. The Transferrin Saturation Profile Among Anaemic Blood Donors
  3. Iron Deficiency Anemia Of Babies
  4. Patients’ Serum Protein Electrophoresis With Normal Serum Total Protein Level
  5. Inflammatory Marker Hs Crp With Hipertension
  6. Comparison Of Kalium Serum Level With Or Without Insulin Therapy At Type 2 Diabetic Mellitus Patiens
  7. Microalbuminuria Of Type 2 Dm Patients
  8. Analysis Of The Immunochromatography And Enzyme-linked Immunosorbent Assay Tests To Diagnose Helicobacter Pylori In Dyspepsia
  9. Soluble Transferrin Receptor Level In Human Immunodeficiency Virus/acquired Immunodeficiency Syndrome Patients With Anemia
  10. Comparison Of Specthrophotometer Method With Hemocue Method For Haemoglobin Measurement In Leucocytosis Sample
  11. Toll-like Receptor (tlr) And Natural Immunity
  12. A Retinoid Acid Receptor In Acute Promyelocytic Leukemia Auer Rods
  13. Errors During Clinical Laboratoric Procedures

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