UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 16 / No. 1 / Published : 2009-11

Related with : Scholar   Yahoo!   Bing

Original Article :

Study of cd38 expression on lymphocyte 8+, cd4+ profile, and clinical state immunological and clinical state profile of aids/hiv patients with antiretroviral therapy)

Author :

  1. Ira Puspitawati*1
  2. Umi S. Intansari*2
  1. Bagian Patologi Klinik FK UGM Yogyakarta
  2. Bagian Patologi Klinik FK UGM Yogyakarta

Abstract :

The relationship between immune activation and pathogenesis of Human Immunodeficiency Virus (HIV) infection is unproven. It has been hypothesized that state that HIV-induced activation enhances the magnitude of HIV replication other study shown that viral replication impaired immune activation. One of the best immune activation marker is CD38 expression on CD8+ because it has the strongest significant prognostic markers. It was previously shown that increased CD8+ T-cell activation has predictive value for disease progression but the relation is still controversial. One hypothesis state that HIV-induced activation enhances the magnitude of HIV replication, other said that viral replication impaired immune activation. To know the profile of immunology and clinical state of HIV/AIDS patients by determining the CD38 molecule expression on CD8+ cells as an activation marker, CD4+ profiles and clinical state. Crosssectonal, observasional study was done. Twenty nine HIV/AIDS patients who routinely had medical check up and having routine antiretroviral therapy at Sardjito hospital and 8 healthy people as normal controls were involved in this study. The count of CD4+ cells absolute counts and expression of CD38 molecule on CD8 cells were measured using flowcytometry. The CD4+ counts had significant negative correlation with WHO stage (p = 0.012). Expression of CD38 molecule on CD8+ cells of HIV/AIDS patients were higher compared to normal controls, 209.29 ± 76.56, 109.61 + 32.29 respectively (p < 0.05). That expression was not correlated with CD4+ counts and CD4+ increment. It might be caused by the time of measurement was not at the begining of diseases. The CD4+ increment after therapy was statistically significant (p = 0.003). The CD4+ count was negatively correlated with the WHO stage. Expression of CD38 molecule on CD8+ cells of HIV/AIDS patients were significantly higher compared to normal controls but it wasn’t correlated with the CD4+ number and CD4+ increment after therapy.

Keyword :

CD38, immune activation, HIV/AIDS, CD8+ cells, CD4+ cells,


References :

Djoerban Z, Djauzi S,(2006) HIV/AIDS di Indonesia Jakarta : Pusat penerbitan dep ilmu penyakit dalam FK UI





Archive Article

Cover Media Content

Volume : 16 / No. : 1 / Pub. : 2009-11
  1. Homolog Legionella Pneumophila Distribution And Nosocomial Pneumopniae
  2. Diagnostic Value Of Malaria Antigen Cassette On Malaria Disease
  3. Cd4 Analysis In Treatment Of Hiv-tb Co-infected Patients
  4. Analysis Of Uric Acid Level In Patients Of Carcinoma Mammae
  5. Anti Hcv And The Patient’s Prevalence Of Virus Hepatitis C Infection
  6. The Evaluation Of Transaminase Activities, And Bilirubin Level In Patients With Hepatitis B Virus And C Virus
  7. Correlation Degree Of Non-alcoholic Fatty Liver With Aminotransferase Serum Activity
  8. Accuracy Of Bactident Aminopeptidase Test In Identification Gram Negative Bactery)
  9. Study Of Cd38 Expression On Lymphocyte 8+, Cd4+ Profile, And Clinical State Immunological And Clinical State Profile Of Aids/hiv Patients With Antiretroviral Therapy)
  10. Eosinofil After Mucosal Nasal Brushing And Routine Hematology In Allergy Rhinitis
  11. Normoblast Counting Between Acute Myeloblast Leukemia And Acute Lymphoblastic Leukemia In Peripheral Blood Smear Of Patients
  12. Measurement And Clinical Application Of Thrombin Activatable Fibrinolysis Inhibitor
  13. Abnormal Trombosit In Post-partum
  14. Laboratory Costing Per Test Based On Jaros Ml Method

Information CPML