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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 21 / No. 1 / Published : 2014-01

TOC : 11, and page :50 - 56

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Original Article :

T-cd4+ and lipid profile in hiv)

Author :

  1. Yulia Hayatul Aini*1
  2. Coriejati Rita*2
  3. Agnes Rengga Indrati*3
  4. Rudi Wisaksana*4
  1. Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung
  2. Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung
  3. Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung
  4. Patologi Klinik Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung

Abstract :

Human Immunodeficiency Virus (HIV) infection patients are often reported to be associated with changes of lipid metabolism. A previous study suspected that there was a correlation between low CD4+ T-lymphocyte counts with the lipid profile in HIV-infected patients. The objective of this study was to know the assessment of the lipid profile (total cholesterol, HDL, LDL and triglyceride) in patients with HIV infection and their correlation with CD4+ T-Lymphocyte count. This study was conducted at the Hasan Sadikin Hospital, Bandung using retrospective data, and analysis method as the study design. The study was performed on 402 HIV-infected patients. A significant difference was found in all lipid parameters between patients with and without ART (p<0.05). Weak correlations were found between CD4+ T-Lymphocyte with total cholesterol and HDL levels (r<0.04), and a very weak correlation as well with the LDL level (r<0.2). There was no correlation with the triglyceride levels (p=0.751). The lipid profile showed a weak correlation with CD4+ T-Lymphocyte, therefore, it can not be used as a parameter to know the severity of disease relating to the HIV infection. However, it can be useful for monitoring the metabolic effect of the given therapy, because there was a significant difference between those patients with and without ART. Pasien pengidap infeksi Human Immunodeficiency Virus (HIV) sering dilaporkan berkaitan dengan ada perubahan pada metabolisme lipid. Telitian sebelumnya menduga terdapat kenasaban antara jumlah limfosit T-CD4+ yang rendah dan profil lipid di pasien yang terinfeksi HIV. Penelitian ini bertujuan untuk mengetahui profil lipid (jumlah keseluruhan kolesterol, HDL, LDL dan trigliserida) di pasien infeksi HIV serta kenasabannya dengan jumlah limfosit T-CD4+. Penelitian ini dilakukan di Rumah Sakit Hasan Sadikin Bandung dengan data retrospektif. Rancangan penelitian menggunakan metode analisis. Subjek penelitian adalah pasien yang terinfeksi HIV. Penelitian ini dilakukan di 402 pasien. Ditemukan hasil berbeda bermakna antara subjek yang menerima ART dan yang tanpa (p<0,05) di semua tolok ukur lipid. Kenasaban yang lemah ditemukan antara limfosit T-CD4+ dan kadar jumlah keseluruhan kolesterol dan HDL (r<0,4), sedangkan yang dengan LDL sangat lemah (r<0,2). Kenasaban antara limfosit T-CD4+ dan kadar trigliserida (p=0,751) tidak ada. Profil lipid memiliki kenasaban yang lemah dengan limfosit T-CD4+, sehingga tidak dapat dijadikan tolok ukur untuk melihat derajat keparahan penyakit infeksi HIV, tetapi dapat berperan dalam memantau dam

Keyword :

Antiretroviral, CD4+, human immunodeficiency virus, lipid profile,


References :

  1. Singh A, (2011). HIV prevalence in suspects attending Sir Sunder Lal Hospital. vol 1 No1 Hal 69-73 : Asian Pac J Trop Biomed
  2. Pasupathi P, Bakthavathsalam G, (2008). Changes in CD4 cell Count, Lipid Profile and Liver Enzymes in HIV Infection and AIDS Infection. vol 6 Hal 139-45 : J Appl Biomed


   


Archive Article

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Volume : 21 / No. : 1 / Pub. : 2014-01
  1. The level of interleukin-6 plasma in diabetes mellitus patients with and without diabetic retinopathy
  2. Correlation plasma fibrinogen with intima-media thickness of carotid artery in diabetes mellitus
  3. Matrix metalloproteinase-2 in breast cancer metastastis
  4. Potassium in multidrug resistance tuberculosis with kanamycin
  5. Safe blood and voluntary non-remunerated blood donors
  6. Mean platelet volume in diabetes mellitus
  7. Ratio of urinary uric acid levels and serum uric acid in type 2 diabetes mellitus
  8. Reticulocyte hemoglobin level of absolute iron deficiency anemia and nonabsolute iron deficiency anemia in end state renal disease undergoing maintenance hemodialysis
  9. Immature platelet fraction in dengue fever and dengue hemorrhagic fever
  10. Cryptococcal antigen of acquired immune deficiency syndrome with lateral flow assay and cryptococcus antigen latex agglutination system
  11. T-cd4+ and lipid profile in hiv)
  12. Liver function parameters based on degree of liver fibrosis in chronic liver disease
  13. Brain derived neurotrophic factor (bdnf) as a prognostic factor in severe head injury
  14. Hpv genotype and hpv infection pattern related to the histopathological type of cervical cancer)
  15. Glut 4 in adipose tissue
  16. The diagnostic value of anti dengue iga and anti dengue igm/igg in dengue virus infection)
  17. Vitamin d deficiency and diseases
  18. Lineage switch from acute lymphoblastic leukemia to acute myelomonocytic leukemia at a 26 years old woman
  19. The role for clinical pathologist in hospital accreditation