UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 17 / No. 2 / Published : 2010-11

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Original Article :

The chemotherapy effect in the activity of transaminase enzymes in breast cancer patients

Author :

  1. Helena Leppong*1
  2. Mutmainnah*2
  3. Uleng Bahrun*3
  1. Departemen Patologi Klinik FK UNHAS Jl. Perintis Kemerdekaan Tamalanrea Makassar Telp 0411-581226
  2. Departemen Patologi Klinik FK UNHAS Jl. Perintis Kemerdekaan Tamalanrea Makassar Telp 0411-581226
  3. Departemen Patologi Klinik FK UNHAS Jl. Perintis Kemerdekaan Tamalanrea Makassar Telp 0411-581226

Abstract :

Breast cancer is one of the malignancies with unknown exact aetiology. The management of breast cancer can be done by several ways including it’s related chemotherapy. This therapy leads to cancer cells damage as well as healthy liver cells. Aspartate transaminase (AST) and Alanine transaminase (ALT) are the sensitive parameters to evaluate hepatocellular damage, the levels will raise rapidly in liver cells injury. The objective of this study was to evaluate the effect of chemotherapy in the activity of liver transaminase enzymes of breast cancer patients. A cross-sectional study was conducted by taking data from Medical Records of breast cancer patients who received chemotherapy at the Dr. Wahidin Sudirohusodo Hospital Makassar during the period of May 2008–May 2009. The data were analyzed statistically by t-Test using SPSS software for Windows version 11.5. From 71 evaluated samples, the level of the liver transaminase enzymes in all grades of cancer did not show a significant change (p>0.05). Chemotherapy of breast cancer patients does not increase the activity of transaminase enzymes. In this study, the level of AST and ALT in chemotherapy patients can not predict the liver function disorder.

Keyword :

Chemotherapy, AST, ALT,


References :

Wallach J,(2007) Laboratoy Test for Disease Liver Philadhelpia : Lippincott Williams and Wilkins





Archive Article

Cover Media Content

Volume : 17 / No. : 2 / Pub. : 2010-11
  1. The Diagnostic Value Of Heart-type Fatty Acid Binding Protein (h-fabp) Rapid Test Related To Cardiac Troponin I In Non St Elevation Myocardial Infarction (nstemi)
  2. The Creatinine Level And Potassium Serum In Patients With And Without Type Ii Diabetic
  3. Procalcitonin For The Differentiation Of Bacterial And Non Bacterial Infection
  4. Diagnosis Of Dengue Virus Infection With Iga Anti Dengue Rapid Tests
  5. The Platelet Aggregation Test As A Predictor Of Clinical Outcome In Acute Infarction Stroke
  6. Association Between Atypical Depolarization On The Cell-dyn 3200 And The Presence Of Plasmodium Spp In Blood In The Dr. Soetomo Hospital Surabaya
  7. The Correlation Between Thrombocyte And Cd4 Count In Hiv/aids Patients
  8. The Chemotherapy Effect In The Activity Of Transaminase Enzymes In Breast Cancer Patients
  9. Pathogenesis And Laboratory Examination Of Primary Myelofibrosis
  10. Star ()-flagged Leukocytosis As Indicator Of Interfering Factor In Automatic Hematology Analyzer
  11. (oral Administration Of Mycobacterium Tuberculosis 38-kilodalton Adhesin Protein Increases Macrophages And Lymphocytes In Intestinal Balb/c Mice)
  12. Diazo Test As A Screening Test Of Typhoid Fever A Practical Approach

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