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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 14 / No. 3 / Published : 2008-07

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Original Article :

The corelation between leukemia plasma cell and myelofibrosis

Author :

  1. Sri Sulistiandari*1
  2. Budiman*2
  1. Departemen Patologi Klinik Fakultas Kedokteran Universitas Brawijaya/RSU Dr. Saiful Anwar Malang
  2. Departemen Patologi Klinik Fakultas Kedokteran Universitas Brawijaya/RSU Dr. Saiful Anwar Malang

Abstract :

Plasma cell leukemia (PCL) is a variant form of myeloma which contain more than >20% plasma cells and an absolute plasma cell content ≥ 2.000/mm3 in peripheral blood. PCL is a rare disorder, whole PCL with myelofibrosis is even more rare disorder. The correlation between plasma cell leukemia and myelofibrosis is unclear. A 59-years-old woman referred to our hospital with general weakness and severe anemia. Physical examination: looks pale, anaemic of conjunctiva, hepatosplenomegaly. The laboratory findings are Hb 4.1 gr/dL, MCV 81 fL, MCH 26.7 pg, leucocytes 22.500/mm3, thrombocytes 26.000/mm3, reticulocytes 1.8%. The peripheral blood showed leucoerythroblastic morphology with teardrop cells and 32% plasma cells. Bone marrow aspiration revealed massive plasma cell infiltrations (90%). Protein electrophoresis showed hypogammaglobulinemia. There is no evidence of osteolitic bone lesion on radiological examination. Clinical and laboratory finding above support the diagnosis of Primary Plasma Cell Leukaemia that may lead to myelofibrosis as a complication. Bone marrow biopsy is required to confirm diagnosis of myelofibrosis

Keyword :

Plasma cell leukemia, myelofibrosis,


References :

  1. Dispenzieri A, Lacy MQ, Greip PR, (2004). Multiple myeloma in greer. London : Wintrobes clinical hematology


   


Archive Article

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Volume : 14 / No. : 3 / Pub. : 2008-07
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  2. Lactic acid profile in controlled and uncontrolled diabetes mellitus patients
  3. Ldl related risk markers for coronary heart disease
  4. Evaluation of sensitivity and specificity of troponin i and troponin t as cardiac biochemical markers in the early diagnosis of acute myocardial infarction (ami)
  5. Rapid test for igm antibodies salmonella typhi of typhoid fever
  6. The immunosupression of renal transplantation) (part ii
  7. The corelation between leukemia plasma cell and myelofibrosis
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