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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 14 / No. 1 / Published : 2007-11

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Original Article :

The correlation between fibrinogen and concentration microalbuminuria in type 2 diabetic patients

Author :

  1. Rikarni -*1
  2. Lillah -*2
  3. Yoesri -*3
  1. Bagian Patologi Klinik RSUP Dr. M. Djamil Padang
  2. Bagian Patologi Klinik RSUP Dr. M. Djamil Padang
  3. Bagian Patologi Klinik RSUP Dr. M. Djamil Padang

Abstract :

Increase of fibrinogen concentration in type 2 diabetic patients is an indicator for vascular inflammation, endothelial dysfunction. Hyperfibrinogenemia is a strong marker and independently for atherosclerosis. Beside that, hyperfibrino -genemia can precede macro and microvascular complication. In type 2 diabetic, microalbuminuria is early marker for diabetic nephropathy and show that there is endothelial dysfunction. Microalbuminuria not only useful to predict renal damage, but also useful to predict cardiovascular damage. Microalbuminuria is a marker for endothelial dysfunction. To know the correlation between increase of fibrinogen concentration and microalbuminuria in type 2 diabetic patients. The study was performed in Dr. M. Djamil central Hospital by using cross sectional method and consecutive random sampling. Sample were type 2 diabetic patients included criteria were measured albumin/ creatinine ratio and the patients was divided in 2 group, that is group A (normoalbuminuria) and group B (microalbuminuria) with total sample were 90 patients. Each group were performed measurement of albumin/ creatinine ratio, random glucose concentration, and fibrinogen concentration in plasma. In group A, we found the average of albumin/ creatinine ratio is 6.6 μg/mg and in group B is 107.5 μg/mg. The average of random glucose concentration in group A is 181.3 mg/dl, and in group B is 204 mg/dl and the difference of concentration is not significantly (p > 0.05). The average of fibrinogen concentration in group A is 383.5 ± 104.6 mg/dl, and in group B is 467 ± 79 mg/dl. Increasing fibrinogen concentration in group B is higher than group A and the increasing is significantly statistical difference (p

Keyword :

fibrinogen, microalbuminuria,


References :

  1. Deinum J, Derkx FHM, (2000). Cystatin for estimation of Glomerular Filtration Rate. Washington DC : Lancet


   


Archive Article

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Volume : 14 / No. : 1 / Pub. : 2007-11
  1. Conversion of afb sputum between standard in 1st category group with high dose rifampicin of antituberculose therapy
  2. The correlation between fibrinogen and concentration microalbuminuria in type 2 diabetic patients
  3. Diagnostic value of a quantitative immunochromatography assay for troponin i
  4. The effect of calorie restriction to serum hydrogen peroxide level and glucose blood level in old mice
  5. Erythropoietin physiology, clinical, and laboratory aspect
  6. Dic/disseminated intravascular coagulation caused by venom snake bite
  7. The level of n terminal-pro brain natriuretic peptide in hypertensive heart disease patients
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