UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 16 / No. 2 / Published : 2010-03

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Original Article :

The diagnosis molecular and aplication in treatment of b & c hepatitis

Author :

  1. Aryati*1
  1. Departemen Patologi Klinik FK Universitas Airlangga – RSUD Dr. Soetomo Jl. Prof. Mayjen Moestopo 6-8 Surabaya

Abstract :

In the whole world, up to now hepatitis B and C virus are still the main causes of chronic hepatitis, cirrhosis until hepatocellular carcinoma. Most diagnosis is based on a serological examination such as the determination of antigen and antibody, for example HbsAg, HbeAg and anti HCV. Recently, for hepatitis C examination, HCV core antigen is used for the detection of HCV infection during the window period, chronic C hepatitis and for treatment monitoring. At present, serological assays are not sufficient to confirm the diagnosis of hepatitis B and C due to mutations of false negative HbsAg or HbeAg results. Occult hepatitis B can occur with a negative result of HbsAg, which cause difficulties in confirming the diagnosis and treatment as well. The success of treatment can be influenced of both hepatitis B and hepatitis C that have genotypes. By using molecular examination, such as determination of HBV-DNA and HCV-RNA, it is expected that the problem of serological determination can be overcome. Molecular examination is not only useful for just the diagnosis confirmation, such as for active phase and replicative determination. This sequence is also very useful as a data base prior to the treatment of hepatitis B and hepatitis C as well as for their following success result.

Keyword :

HBV-DNA, HCV-RNA, diagnosis and treatment,


References :

Ozaraz R, Tabak F, Tahan V, Oztruk R et all,(2008) Correlation of quantitative assay of HBsAG and HBV DNA levels during chronic HBV treatment New York : Springer Sciences





Archive Article

Cover Media Content

Volume : 16 / No. : 2 / Pub. : 2010-03
  1. Serum Albumin Level In Ischemic And Hemorrhagic Stroke Patients
  2. Microbial Resistance And Sensitivity Pattern To Antimicrobial Drug
  3. Various Bacterial Cultures Related To Their Susceptibility Against Several Types Of Antibiotics
  4. Analysis Of Eosininophil On Acute Interstitial Nephritis
  5. Von Willebrand Kinetic Factor In Adult Dengue Haemorrhagic Fever Patients
  6. Immature To Total Neutrophil (i/t) Ratio As Septic Neonatorum Diagnostic
  7. Hdl Cholesterol Concentration Measured Using Cholestest N Hdl And Hdl-c Plus 3rd Generation Reagents
  8. Molecul Detection Of Rpob Gene Mutation In Mycobacterium Tuberculosis With Polymerase Chain Reaction And Singgle Strand Conformation Polymorphism
  9. The Diagnosis Molecular And Aplication In Treatment Of B & C Hepatitis
  10. Swine Influenza A/h1n1 Confirmed By Pcr
  11. Sd Dengue Duo (ns1, Igg, Igm) Rapid Test For The Diagnosis Of Dengue Virus Infection
  12. The Management Of An Emergency Laboratory

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