UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 17 / No. 2 / Published : 2010-11

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Original Article :

The diagnostic value of heart-type fatty acid binding protein (h-fabp) rapid test related to cardiac troponin i in non st elevation myocardial infarction (nstemi)

Author :

  1. F.R. Marpaung1*1
  2. Aryati*2
  3. Sidarti Soehita SFHS*3
  4. Yogiarto*4
  5. Yusri*5
  1. Departemen Patologi Klinik, Fakultas Kedokteran Universitas Airlangga/RSUD Dr. Soetomo Surabaya.
  2. Departemen Patologi Klinik, Fakultas Kedokteran Universitas Airlangga/RSUD Dr. Soetomo Surabaya
  3. Departemen Patologi Klinik, Fakultas Kedokteran Universitas Airlangga/RSUD Dr. Soetomo Surabaya
  4. Departemen Penyakit Jantung, Fakultas Kedokteran, Universitas Airlangga/RSUD Dr. Soetomo Surabaya
  5. Departemen Penyakit Jantung, Fakultas Kedokteran, Universitas Airlangga/RSUD Dr. Soetomo Surabaya

Abstract :

Acute coronary syndrome (ACS) is caused by atherosclerotic plaque rupture and microembolization which lead to decreased oxygen supply into the myocardium. Generally, ACS includes an unstable angina (UA), non ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction. ACS may lead to ST elevation Myocardial Infarction (STEMI) and finally a sudden death. Cardiac troponin is used routinely for diagnosing acute coronary syndrome (ACS); however, troponin is not elevated in the initial hours of ACS—precluding their usefulness in the early diagnosis. The aim of this study is to determine the diagnostic value of h-FABP Rapid test in relation to Cardiac Troponin I in NSTEMI. Seventy five patients with ACS were enrolled in this study. All patients presented symptoms within six hours of the onset and suffered typical chest pain. Blood samples were obtained for rapid test h-FABP (cardiodetect) and Troponin I (tropospot). The h-FABP showed a 93.5% sensitivity, 95% CI: 81.1–98.3 and 82.8% specificity, 95% CI: 63.5–93.5, Positive Predictive Value 89.6%, 95% CI: 76.6–96.1, Negative Predictive Value 88.9%, 95% CI: 69.7–97.1, respectively in the first six hours. Troponin I had a 60.9% sensitivity, 95% CI: 45.4–74.5 and 96.6% specificity, 95% CI: 80.4–99.8, Positive Predictive Value 96.6%, 95% CI: 80.4–99.8, Negative Predictive Value 60.9%, 95% CI: 45.4–74.5, respectively in the first six hours. Based on this study result on patients with Non ST Elevation Myocardial Infarction (NSTEMI), it is suggested to determine the h-FABP as well. For this purpose, point-of-care h-FABP test can be utilized, as it has the advantage of highly sensitivity and specificity, beside it can carry on a bedside testing and show a rapid test results as well.

Keyword :

h-FABP, Troponin I, NSTEMI, UA,


References :

Tsung H,(1981) Several Condition Causing Elevation of Serum CK-MB and CK-BB Washington DC : Am J Clin Pathol





Archive Article

Cover Media Content

Volume : 17 / No. : 2 / Pub. : 2010-11
  1. The Diagnostic Value Of Heart-type Fatty Acid Binding Protein (h-fabp) Rapid Test Related To Cardiac Troponin I In Non St Elevation Myocardial Infarction (nstemi)
  2. The Creatinine Level And Potassium Serum In Patients With And Without Type Ii Diabetic
  3. Procalcitonin For The Differentiation Of Bacterial And Non Bacterial Infection
  4. Diagnosis Of Dengue Virus Infection With Iga Anti Dengue Rapid Tests
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  6. Association Between Atypical Depolarization On The Cell-dyn 3200 And The Presence Of Plasmodium Spp In Blood In The Dr. Soetomo Hospital Surabaya
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  11. (oral Administration Of Mycobacterium Tuberculosis 38-kilodalton Adhesin Protein Increases Macrophages And Lymphocytes In Intestinal Balb/c Mice)
  12. Diazo Test As A Screening Test Of Typhoid Fever A Practical Approach

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