UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 14 / No. 1 / Published : 2007-11

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Original Article :

The level of n terminal-pro brain natriuretic peptide in hypertensive heart disease patients

Author :

  1. Febria Asterina*1
  2. B Nasution*2
  3. N Akbar*3
  1. Departemen Patologi Klinik,
  2. Departemen Patologi Klinik,
  3. Departemen Jantung dan Pembuluh Darah, Fakultas Kedokteran Universitas Sumatera Utara/RSUP H. Adam Malik Medan

Abstract :

Patients with hypertension are at high risk for development of Left Ventricle Hypertrophy (LVH) and Left Ventricular Systolic Dysfunction (LVSD). These conditions should be identified earlier to prevent cardiac morbidity and mortality. To measured serum level of NT-proBNP in hypertensive and mild symptomatic Hypertensive Heart Disease (HHD) patients (NYHA class I-II), to perform echocardiography evaluation to all of the patients and associated with serum level of NT-proBNP. A cross sectional study was done at H. Adam Malik Hospital Medan, participants were recruited from consecutive samples of 15 hypertensive and 16 mild symptomatic HHD patients whose visited cardiovascular and internal medicine out patient clinics. Of these patients, blood samples were taken and a two dimension echo-Doppler study was performed. The patients divided into three groups based on echocardiography studies respectively: Group 1: 9 hypertensive patients with normal echocardiography finding; group 2: 13 patients with LVH and ejection fraction (EF) ≥ 60%; and group 3: 9 patients with LVH and EF < 60%. Mean NT-proBNP serum level (in pg/mL) for groups 1-3 respectively, were: 56.4 ± 34.5, 245.4 ± 339.2 and 852.0 ± 1218.9. Mean NT-proBNP serum level differed among all three groups (p = 0.050), but the significant difference found between group 1 and group 3 (p < 0.05) only. There were significant correlation between NT-proBNP serum level and the three stages of echocardiography finding (r = 0.488 and p = 0.005). The result suggests that NT-proBNP serum level correlated with deterioration of heart function and structure according echocardiography studies. The Significant rise in NT-proBNP serum level happened only when Left Ventricular Systolic Dysfunction (LVSD) develops in hypertension.

Keyword :

HHD (hypertensive heart disease), NT-proBNP (N Terminal-Pro Brain Natriuretic Peptide),


References :

Kaplan NM, Lieberman E,(1998) Primary Hypertension Baltimore : Williams and Witkins





Archive Article

Cover Media Content

Volume : 14 / No. : 1 / Pub. : 2007-11
  1. Conversion Of Afb Sputum Between Standard In 1st Category Group With High Dose Rifampicin Of Antituberculose Therapy
  2. The Correlation Between Fibrinogen And Concentration Microalbuminuria In Type 2 Diabetic Patients
  3. Diagnostic Value Of A Quantitative Immunochromatography Assay For Troponin I
  4. The Effect Of Calorie Restriction To Serum Hydrogen Peroxide Level And Glucose Blood Level In Old Mice
  5. Erythropoietin Physiology, Clinical, And Laboratory Aspect
  6. Dic/disseminated Intravascular Coagulation Caused By Venom Snake Bite
  7. The Level Of N Terminal-pro Brain Natriuretic Peptide In Hypertensive Heart Disease Patients
  8. Satisfaction Of Internal Customer

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