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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 16 / No. 3 / Published : 2010-07

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Original Article :

The role of ns-1 dengue antigen to thrombolytic count and clinical manifestation of dengue viral infection

Author :

  1. J Nugraha*1
  2. T.E Widijatmoko*2
  1. Departemen Patologi Klinik FK Universitas Airlangga – RSUD Dr. Soetomo Jl. Prof. Mayjen Moestopo 6-8 Surabaya
  2. Departemen Patologi Klinik FK Universitas Airlangga – RSUD Dr. Soetomo Jl. Prof. Mayjen Moestopo 6-8 Surabaya

Abstract :

Dengue virus infection has become the major health problem in Indonesia. Dengue haemorrhagic fever is a part of dengue virus infection. 95% of this disease commonly affects children less than 15 years. However, in the last five years the incidence of DHF has also increased in adults. In 2008, the case fatality rate of DHF was 0.99% in East Java and 0.47% in Surabaya. The diagnosis of DHF is based on the 1997 WHO criteria. Thrombocytopenia is a haematological abnormality occurring in DHF. There is a hypothesis about the role of non-structural 1 antigen (NS1 antigen) during initial virus replication leading to immunological reaction manifestation in thrombocytopenia. To analyze the role of NS1 antigen dengue to platelet count and clinical manifestations to know the degree of dengue virus infection. This study used a cross-sectional design. The samples are comprised of 52 patients with dengue fever and dengue haemorrhagic fever grade I until III hospitalized at Tropical Disease Ward, Dr.Soetomo Hospital, and Surabaya. Data were analyzed using Mann-Whitney test, t-two sample test (p = 0.05). The result of this study using Mann-Whitney test show no difference between NS1 antigen dengue with the clinical manifestations in dengue virus infection (p = 0.882). Analysis using t-two sample test showed a significant difference between NS1 antigen dengue positive and NS1 antigen dengue negative with a change in platelet count(p = 0.006). Although, the test showed no significant difference between NS1 antigen dengue and the platelet count in dengue virus infection (p = 0.062). There were found no significant association between NS1 dengue antigen with platelet count and clinical manifestations in dengue virus infection.

Keyword :

NS1 antigen dengue, platelet count, clinical manifestations , dengue virus infection,


References :

  1. Soewandojo E, Nasronudin , (2001). Tata laksana demam berdarah dengue pada orang dewasa. Surabaya : Airlangga University Press


   


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Volume : 16 / No. : 3 / Pub. : 2010-07
  1. Hyperuricemia is prognostic factor for clinical outcome in infarction stroke
  2. The role of ns-1 dengue antigen to thrombolytic count and clinical manifestation of dengue viral infection
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