UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 15 / No. 3 / Published : 2009-07

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Original Article :

Toll-like receptor (tlr) and natural immunity

Author :

  1. Suprapto Ma’at*1
  1. Departemen Patologi Klinik FK-Universitas Airlangga - RS. Dr. Soetomo Jl. Prof. Dr. Moestopo 6-8 Surabaya

Abstract :

In all living species, the first line of defence against microbial aggressions is constituted by innate immunity. Toll-like receptors (TLRs) are a family of pattern recognition receptors that are activated by specific components of microbes and certain host molecules. They constitute the first line of defense against many pathogens and play a crucial role in the function of the innate immune system. Recognition of pathogen-associated molecular pattern (PAMP) by TLR, alone or heterodimerization with other TLR or non-TLR receptors, induces signals responsible for the activation of genes important for an effective host defense, especially proinflammatory cytokines, or initiates signal transduction pathways, which trigger expression of genes. These gene products control innate immune responses and further instruct development of antigen-specific acquired immunity.

Keyword :

Toll-like receptor, imunitas natural,


References :

Hopkins PA, Srikandan S,(2005) Mammalian Toll Like Receptors London : Clin Exp Immunol





Archive Article

Cover Media Content

Volume : 15 / No. : 3 / Pub. : 2009-07
  1. Cd4 Cell Counts With Igm Herpes Simplex-type 2 In Hiv Patients
  2. The Transferrin Saturation Profile Among Anaemic Blood Donors
  3. Iron Deficiency Anemia Of Babies
  4. Patients’ Serum Protein Electrophoresis With Normal Serum Total Protein Level
  5. Inflammatory Marker Hs Crp With Hipertension
  6. Comparison Of Kalium Serum Level With Or Without Insulin Therapy At Type 2 Diabetic Mellitus Patiens
  7. Microalbuminuria Of Type 2 Dm Patients
  8. Analysis Of The Immunochromatography And Enzyme-linked Immunosorbent Assay Tests To Diagnose Helicobacter Pylori In Dyspepsia
  9. Soluble Transferrin Receptor Level In Human Immunodeficiency Virus/acquired Immunodeficiency Syndrome Patients With Anemia
  10. Comparison Of Specthrophotometer Method With Hemocue Method For Haemoglobin Measurement In Leucocytosis Sample
  11. Toll-like Receptor (tlr) And Natural Immunity
  12. A Retinoid Acid Receptor In Acute Promyelocytic Leukemia Auer Rods
  13. Errors During Clinical Laboratoric Procedures

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