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Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 21 / No. 1 / Published : 2014-01

TOC : 17, and page :90 - 95

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Original Article :

Vitamin d deficiency and diseases

Author :

  1. Pusparini*1
  1. Bagian Patologi klinik Fakultas Kedokteran Universitas Trisakti

Abstract :

It has been estimated that deficiency and insufficiency of Vitamin D affect one bilion people worldwide. Vitamin D deficiency can be found not only in countries with four (4) seasons, but also in countries with sunlight exposure all year long The objective of this study was to know whether vitamin D deficiency can occur in Indonesia as well and to explore the role of vitamin D in people‘s health, although Indonesia is a country in the equator region. To avoid long term negative health consequences 25 hydroxyvitamin D/25 (OH) D serum level should be between 30 and 100 ng/mL. The main source of vitamin D is by synthesis at the skin which is exposed to ultraviolet B radiation. The other source of vitamin D is from food. There are a lot of causes of vitamin D deficiency, for example: decreased vitamin D synthesis, nutritional intake of vitamin D, maternal vitamin D stores and exclusive breastfeeding, mal absorption and decreased synthesis or increased degradation of 25 (OH) D. From the above factors, decreased vitamin D synthesis is the main cause of vitamin D deficiency. The vitamin D deficiency is estimated and plays an important role in multiple disorders, such as: osteoporosis, fracture, cancer, cardiovascular disease, diabetes mellitus, autoimmune disease and infectious disease. A good strategy in managing vitamin D deficiency is needed in order to solve the related problems. Defisiensi dan ketidak-cukupan vitamin D di dunia diperkirakan menimpa satu (1) juta penduduk. Defisiensi vitamin D tidak hanya dijumpai di negara dengan empat (4) musim, tetapi juga dijumpai di negara dengan pajanan sinar matahari sepanjang tahun seperti di negara Indonesia. Tujuan penulisan makalah ini adalah untuk mengetahui bentuk ancaman defisiensi vitamin D dengan menelaah kajian dan telitian mutakhir, walaupun Indonesia merupakan negara yang terletak di katulistiwa. Penjelasan tersebut juga dapat menimbulkan pengetahuan kewaspadaan bagi penduduk wilayah tersebut mengenai dampaknya, selain dapat mengetahui dan membahas peran vitamin D bagi kesehatannya. Kadar 25 hidroksi vitamin D/25 (OH) D di dalam darah yang dianjurkan berkisar antara 30−100 ng/mL untuk menghindari gangguan kesehatan. Sumber utama vitamin D adalah pembuatan di kulit yang terpajan sinar ultraviolet B. Sumber vitamin D lainnya adalah dari makanan. Faktor penyebab defisiensi vitamin D bermacam-macam, antara lain penurunan: pembuatan vitamin D, asupan vitamin D dan cadangan vitamin D, pemberian ASI khusus, malabsorbsi dan hal yang terkait pembuatan atau peningkatan kemunduran 25 (OH) D. Kelima faktor tersebut yang terkait penurunan pembentukan vitamin D, adalah merupakan hal yang paling berpengaruh terhadap kejadian defisiensi vitamin D. Defisiensi vitamin D diperkirakan berhubungan dengan berbagai penyakit, antara lain: osteoporosis, fraktur, keganasan, serta penyakit: kardiovaskular, diabetes melitus, autoimun dan infeksi. Keberadaan penyakit/kelainan tersebut diperlukan siasat yang tepat untuk mengatasi defisiensi vitamin D.

Keyword :

25 (OH) D deficiency, UV-B exposure, cardiovascular disease, diabetes mellitus,


References :

  1. Kauffman JM, (2009). Benefits of vitamin D supplementation. vol. 14, Hal: 38-45. : J. of Am Phy Surg
  2. Holick M., (2007). Vitamin D deficiency. Vol. 357 Hal: 266– 81 : N Eng J Med


   


Archive Article

Cover Media Content

Volume : 21 / No. : 1 / Pub. : 2014-01
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  2. Correlation plasma fibrinogen with intima-media thickness of carotid artery in diabetes mellitus
  3. Matrix metalloproteinase-2 in breast cancer metastastis
  4. Potassium in multidrug resistance tuberculosis with kanamycin
  5. Safe blood and voluntary non-remunerated blood donors
  6. Mean platelet volume in diabetes mellitus
  7. Ratio of urinary uric acid levels and serum uric acid in type 2 diabetes mellitus
  8. Reticulocyte hemoglobin level of absolute iron deficiency anemia and nonabsolute iron deficiency anemia in end state renal disease undergoing maintenance hemodialysis
  9. Immature platelet fraction in dengue fever and dengue hemorrhagic fever
  10. Cryptococcal antigen of acquired immune deficiency syndrome with lateral flow assay and cryptococcus antigen latex agglutination system
  11. T-cd4+ and lipid profile in hiv)
  12. Liver function parameters based on degree of liver fibrosis in chronic liver disease
  13. Brain derived neurotrophic factor (bdnf) as a prognostic factor in severe head injury
  14. Hpv genotype and hpv infection pattern related to the histopathological type of cervical cancer)
  15. Glut 4 in adipose tissue
  16. The diagnostic value of anti dengue iga and anti dengue igm/igg in dengue virus infection)
  17. Vitamin d deficiency and diseases
  18. Lineage switch from acute lymphoblastic leukemia to acute myelomonocytic leukemia at a 26 years old woman
  19. The role for clinical pathologist in hospital accreditation