UNIVERSITAS AIRLANGGA



Detail Article

Indonesian Journal of Clinical Pathology and Medical Laboratory

ISSN 0854-4263

Vol. 16 / No. 2 / Published : 2010-03

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Original Article :

Von willebrand kinetic factor in adult dengue haemorrhagic fever patients

Author :

  1. Riat El Khair*1
  2. Usi Sukorini*2
  1. Bagian Patologi Klinik Fakultas Kedokteran Universitas Gadjah Mada Yogyakarta
  2. Bagian Patologi Klinik Fakultas Kedokteran Universitas Gadjah Mada Yogyakarta

Abstract :

Dengue haemorrhagic fever (DHF) is still a problem in Indonesia. It is a syndrome that in most severe form may threaten the patient’s life, primarily through increased vascular permeability due to endothelial dysfunction leading to shock. Von Willebrand factor (vWf) is a blood glycoprotein involved in haemostasis and present in the blood plasma. The vWf is reported as one of dysfunction endothelial marker. However, there is limited information about the kinetics and contribution of vWf in the pathogenesis of DHF in adult patients. In this study, a serial level of vWf was measured as kinetic of plasma vWf. It is expected that, the evidence based medicine will give contribution in the management of DHF patients. Also, in the future a study will be conducted especially about the prediction of shock to know the kinetic of plasma von Willebrand factor in adult dengue haemorrhagic fever patients. A cross-sectional repeated–measurement study was conducted from October 2007 up to January 2008 in the Department of Clinical Pathology at the Sardjito General Hospital Yogyakarta. Subjects who met the eligible criteria were selected i.e. adult patients hospitalized in the Department of Internal Medicine diagnosed as DHF based on WHO criteria and antibody anti-dengue detection. Serial measurement of plasma vWf was determined on days five (5), seven (7) and 15 using enzyme linked fluorescent assay (ELFA) principle. The resulting data was shown graphically and the difference in levels of vWf among the three groups of time was analyzed by Friedman’s test. The study results showed an increase of vWf on day five /5 (218.48 %), followed by 187.08 % on day seven (7). Interestingly, there was a sharp increase of vWf on day 15 (233.80 %). In addition, there were statistically significant different levels of vWf among those three groups (p = 0.00) in adult dengue haemorrhagic fever patients with the von Willebrand kinetic factor showing a fluctuation pattern. There is an increased level of vWf on the fifth (5) day but a decrease on the seventh (7) day. However, there is a sharp increase in the convalescence phase.

Keyword :

Kinetic, von Willebrand factor, dengue haemorrhagic fever.,


References :

Novriani H,(2002) Respon imun dan derajat kesakitan demam berdarah dengue dan dengue shock syndrome Jakarta : Depkes RI





Archive Article

Cover Media Content

Volume : 16 / No. : 2 / Pub. : 2010-03
  1. Serum Albumin Level In Ischemic And Hemorrhagic Stroke Patients
  2. Microbial Resistance And Sensitivity Pattern To Antimicrobial Drug
  3. Various Bacterial Cultures Related To Their Susceptibility Against Several Types Of Antibiotics
  4. Analysis Of Eosininophil On Acute Interstitial Nephritis
  5. Von Willebrand Kinetic Factor In Adult Dengue Haemorrhagic Fever Patients
  6. Immature To Total Neutrophil (i/t) Ratio As Septic Neonatorum Diagnostic
  7. Hdl Cholesterol Concentration Measured Using Cholestest N Hdl And Hdl-c Plus 3rd Generation Reagents
  8. Molecul Detection Of Rpob Gene Mutation In Mycobacterium Tuberculosis With Polymerase Chain Reaction And Singgle Strand Conformation Polymorphism
  9. The Diagnosis Molecular And Aplication In Treatment Of B & C Hepatitis
  10. Swine Influenza A/h1n1 Confirmed By Pcr
  11. Sd Dengue Duo (ns1, Igg, Igm) Rapid Test For The Diagnosis Of Dengue Virus Infection
  12. The Management Of An Emergency Laboratory

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