UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 44 / No. 1 / Published : 2011-03

Order : 11, and page :54 - 58

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Original Article :

expression of matrix metalloproteinase-8 gene in fixed orthodontic patients

Author :

  1. Susilowati*1
  2. Mansjur Nasir*2
  3. Imam Mudjari *3
  4. Thalca Hamid*4
  1. Department of Orthodontics, Faculty of Dentistry, Hasanuddin University, Makassar-Indonesia
  2. Department of Orthodontic, Faculty of Dentistry, Hasanuddin University, Makassar-Indonesia
  3. Department of Dental Public Health, Faculty of Dentistry, Hasanuddin University, Makassar-Indonesia
  4. Department of Orthodontics, Airlangga University, Surabaya-Indonesia

Abstract :

         Background: Orthodontic treatment with fixed appliance produces structural and biochemical changes and breaking the  balance between the synthesis and the breakdown of collagen in the periodontium. Matrix metalloproteinase-8 (MMP-8) plays an important role in the remodeling of periodontal ligament during orthodontic tooth movement. Purpose: The purpose of this  study is to observe the expression of MMP-8 gene in the gingival crevicular fluid (GCF) of fixed orthodontic patients. It is expected that the results can be used as a reference to decide the proper time for elastomeric chain to be reactivated. Methods: Orthodontic fixed appliances were placed on 8 patients and elastomeric chains exerting 75 grams were given to produce canine distalization. GCF samples were collected from the distal side of  upper canines  before force application, 1-, 2-, 3-, and 4 weeks after application consecutively. The samples were analyzed by using RT-PCR. Statistical analyses used were univariate analysis and Mann-Whitney U test. Results: The expression of MMP-8 in the GCF at t0 was 31.3% but the force application elevated its expression  to 65.6% at t1, and then decreased continously at t2, t3, and t4. There was no statistically significant difference of MMP-8 gene expression between t0 and t3. Conclusion: The highest level of MMP-8 gene expression due to orthodontic forces was taken place in the first week, but it declined continously in the following weeks. The proper time to reactivate an elastomeric chain was 3 weeks after application.

Keyword :

MMP-8, fixed orthodontic appliance, reactivation time,


References :

Erbay EF,(2002) Soft tissue profile in Anatolian Turkish adults. Part I: Evaluation of horizontal lip position using different soft tissue analysis. - : Am J Orthod Dentofac Orthop





Archive Article

Cover Media Content

Volume : 44 / No. : 1 / Pub. : 2011-03
  1. The Difference Of Plaque-index Between Blind And Deaf Children Before And After Dental Health Education
  2. Posterior Transverse Interarch Discrepancy On Hbe β Thalassemia Patients
  3. Cytotoxicity Study Of Reconstruction Plate Made Of Stainless Steel 316l Compared To Commercially Pure Titanium On Baby Hamster Kidney-21 Fibroblast Culture
  4. Calcium Hydroxide As Intracanal Dressing For Teeth With Apical Periodontitis
  5. Titanium – Ceramic Restoration: How To Improve The Binding Between Titanium And Ceramic
  6. Acupuncture Analgesia: The Complementary Pain Management In Dentistry
  7. Management Of Anterior Teeth Damage Caused By Complex Caries Through Aesthetic Endorestoration
  8. Changes Of The Sweet Taste Sensitivity Due To Aerobic Physical Exercise
  9. Cost Effectiveness And Quality Of Life Assessment On Dental Filling And Tooth Extraction In Balongsari Public Health Center
  10. Tnf- α Expression On Rats After Inoculated With Candida Albicans And Fed With Neem Extract (azadirachta Indica)
  11. Expression Of Matrix Metalloproteinase-8 Gene In Fixed Orthodontic Patients

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