UNIVERSITAS AIRLANGGA



Detail Article

Dental Journal (Majalah Kedokteran Gigi)

ISSN 1978-3728

Vol. 45 / No. 3 / Published : 2012-09

Order : 7, and page :156 - 160

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Original Article :

Analgesic effect of coconut shell (cocos nucifera l) liquid smoke on mice

Author :

  1. Meircurius Dwi C.S*1
  2. Tantiana*2
  3. Ira Arundina*3
  1. 2Department of Oral Biology Faculty of Dentistry, Universitas Airlangga , Surabaya – Indonesia
  2. 2Department of Oral Biology Faculty of Dentistry, Universitas Airlangga , Surabaya – Indonesia
  3. 2Department of Oral Biology Faculty of Dentistry, Universitas Airlangga , Surabaya – Indonesia

Abstract :

Background: Drugs can be used to eliminate pain by inhibiting the activity of conversing arachidonic acid into prostaglandin.The chemical compositions of coconut shell are cellulose, pentosan, lignin, solvent extraction, uronat anhydrous, nitrogen, and water.One active ingredient in coconut shell is phenyl propanoid (consisting in lignin structure) and guaicol. Phenyl propanoid and guaicolare phenolic compounds that can be used as antioxidant, antiseptic, anti-inflammatory, anesthetic and analgesic. Liquid smoke ofcoconut shell (Cocos nucifera L) contains phenolic compound is believed able to bind a component conversing arachidonic acid intoprostaglandin. Purpose: The study was aimed to examine the analgesic effect of liquid smoke of coconut shell (Cocos nucifera L).Methods: The study was a laboratory experimental research, conducted on 2-3 months old male mice (Mus musculus) with 20-30grams of weight. There were control group and treatment groups each of which had seven mice. Control group was orally given 0.01ml/weight (ml/gr) of distilled water, after 30 minutes 0.01 ml/weight (ml/gr) of acetic acid 0.6% was delivered via intraperitonealinjection. The treatment groups were given liquid smoke of coconut shell (Cocos nucifera L) with the concentrations of 25%, 50%, and100% respectively. The analgesic effect was then determined by decreasing of writhing reflex on mice recorded every 5 minutes for 30minutes. Results: There were significant differences of writhing reflexes in the treatment groups given liquid smoke of coconut shellwith the concentrations of 25%, 50%, and 100%. The higher concentration of liquid smoke the higher its analgesic effect. Conclusion:Liquid smoke of coconut shell (Cocos nucifera L) has analgesic effect.

Keyword :

Analgesic effect, liquid smoke of coconut shell, acetic acid,


References :

Kidd BL,(2001) Mechanism of inflammatory pain - : Br J Anaesthesia





Archive Article

Cover Media Content

Volume : 45 / No. : 3 / Pub. : 2012-09
  1. The Benefit Of Differential Moment Concept In Managing Posterior Anchorage And Avoiding Bite Deepening
  2. Henoch-schönlein Purpura In Children: Its Relation To Oral And Dental Health
  3. Distribution Of Class Ii Major Histocompatibility Complex Antigen-expressing Cells In Human Dental Pulp With Carious Lesions
  4. Medication Intake And Its Influence On Salivary Profile Of Geriatric Outpatients In Cipto Mangunkusumo Hospita
  5. Maternal Endotoxin-induced Fetal Growth Restriction In Rats: Fetal Responses In Toll-like Receptor
  6. Novel Development Of Carbonate Apatite-chitosan Scaffolds Based On Lyophilization Technique For Bone Tissue Engineering
  7. Analgesic Effect Of Coconut Shell (cocos Nucifera L) Liquid Smoke On Mice
  8. Penetration Effect Of Prostaglandin E2 Gel On Oral Mucosa Of Rats
  9. Shear Bond Strength Of Self-adhering Flowable Composite On Dentin Surface As A Result Of Scrubbing Pressure And Duration
  10. Facial Reconstruction Using Polypropylene Mesh After Resection Of Maxillary Ossifying Fibroma
  11. Physical Characteristic Of Brown Algae (phaeophyta) From Madura Strait As Irreversible Hydrocolloid Impression Material

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